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Merck
CN

G8634

Sigma-Aldrich

鸟苷5′-γ-硫代三磷酸 四锂盐 四锂盐

≥90% (contains < 10% GDP, HPLC), powder

别名:

GTP & # 947;S 四锂盐, GTP-γ-S-Li4, 鸟苷5 & # 8242;-O-(3-硫代三磷酸) 四锂盐

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About This Item

经验公式(希尔记法):
C10H12Li4N5O13P3S
CAS号:
分子量:
562.98
Beilstein:
8182249
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥90% (contains < 10% GDP, HPLC)

表单

powder

颜色

white to off-white

溶解性

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

运输

dry ice

储存温度

−20°C

SMILES字符串

[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

AMQXJFWJOAWCPV-ZVQJTLEUSA-J

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相关类别

应用

鸟苷 5′-[γ-硫代]三磷酸四锂盐可用于:
  • 作为裂解缓冲液的组成部分
  • 用于卵母细胞和哺乳动物细胞的膜片钳实验中,保持G蛋白的持续活跃状态
  • 与G蛋白α偶联,研究其对激酶活性的作用

生化/生理作用

GTP-& # 947;-S是一种不可水解的GTP类似物,以其作为G蛋白活化剂的作用而闻名。最近研究已经证明它在体外保护蛋白质免受蛋白水解降解,以酪氨酸激酶依赖的方式刺激葡萄糖转运蛋白4易位,刺激磷脂酶和诱导肌动蛋白聚合

特点和优势

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

Lot/Batch Number

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访问文档库

Chantal Binda et al.
The Journal of biological chemistry, 294(45), 16865-16883 (2019-10-03)
Accumulating evidence indicates that G protein-coupled receptors (GPCRs) interact with Rab GTPases during their intracellular trafficking. How GPCRs recruit and activate the Rabs is unclear. Here, we report that depletion of endogenous L-type prostaglandin D synthase (L-PGDS) in HeLa cells
Jing Geng et al.
Nature communications, 12(1), 3519-3519 (2021-06-12)
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR4 signal-mediated innate
Matthew C Thibodeau et al.
The Journal of biological chemistry, 299(1), 102764-102764 (2022-12-05)
The formation of complexes between Rab11 and its effectors regulates multiple aspects of membrane trafficking, including recycling and ciliogenesis. WD repeat-containing protein 44 (WDR44) is a structurally uncharacterized Rab11 effector that regulates ciliogenesis by competing with prociliogenesis factors for Rab11
Rab27a is an essential component of melanosome receptor for myosin Va
Wu X, et al.
Molecular Biology of the Cell, 13(5), 1735-1749 (2002)
Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway
Sanchez BP, et al.
Cellular Signalling, 21(9), 1444-1454 (2009)

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