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Merck
CN
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文件

G8377

Sigma-Aldrich

鸟苷 5′-单磷酸 二钠盐 水合物

from yeast, ≥99%

别名:

5′-GMP-Na2, 5′-鸟苷酸 二钠盐 水合物

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About This Item

经验公式（希尔记法）:
C10H12N5Na2O8P · xH2O
CAS号:
5550-12-9
分子量:
407.18 (anhydrous basis)
Beilstein:
3586801
EC 号:
226-914-1
MDL编号:
MFCD00151238
UNSPSC代码:
41106305
PubChem化学物质编号:
24895338
NACRES:
NA.51

生物来源

yeast

质量水平

200

检测方案

≥99%

形式

powder

溶解性

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

储存温度

room temp

SMILES字符串

O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H14N5O8P.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1

InChI key

MEKWJTZTMVQYSU-CYCLDIHTSA-L

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相关类别

应用

鸟苷5′-一磷酸适用于：
  • 在大气压，以及288.15、293.15和298.15K下测定核苷酸的密度和粘度以及0.0004至0.0014mol/kg溶液中的呋喃糖
  • 检测和验证用于检测产生AMP和GMP的酶的transcreener法
  • 在使用毛细管IC-MS/MS进行核苷酸定量分析过程中制备核苷酸标准品

生化/生理作用

鸟苷5′-单磷酸（GMP）是一种核糖核苷单磷酸，其可在磷酸化成GTP后通过各种RNA聚合酶掺入核糖核酸（RNA）中。 鸟苷-5′-单磷酸（GMP）可用于研究谷氨酸能神经传递的调节过程。

包装

无底玻璃瓶。内含物装在插入的融合锥内。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Marcelo Ganzella et al.
Purinergic signalling, 8(1), 49-58 (2011-09-02)
Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic neurotransmission. The aim of this study was to evaluate the effects of chronically administered
Robbin R Vernooij et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 24(22), 5790-5803 (2018-01-10)
The photodecomposition mechanism of trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ] (1, py=pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption, and UV/Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and
Roberto Farina Almeida et al.
Pharmacology, biochemistry, and behavior, 96(3), 306-311 (2010-06-23)
The glutamatergic system has received considerable attention over the last few years as potential target to develop anxiolytic drugs. Guanine based purines (GBPs) play an important neurmodulatory effect in the glutamatergic system. Several studies have shown the ability of the
Simone Molz et al.
Neurochemical research, 30(1), 83-89 (2005-03-11)
Guanosine-5'-monophosphate (GMP) was evaluated as a neuroprotective agent against the damage induced by glutamate in rat hippocampal slices submitted to glucose deprivation. In slices maintained under physiological conditions, glutamate (0.01 to 10 mM), Kainate, alpha-amino-3-hydroxi-5-methylisoxazole-propionic acid (AMPA), N-methyl-D-aspartate (NMDA), 1S,3R-aminocyclopentane-1,3-dicarboxylic
Matt Staeben et al.
Assay and drug development technologies, 8(3), 344-355 (2010-02-18)
Screening of AMP- and GMP-producing enzymes such as phosphodiesterases (PDEs), ligases, and synthetases would be simplified by the ability to directly detect unmodified nucleoside monophosphates. To address this need, we developed polyclonal and monoclonal antibodies that recognize AMP and GMP
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实验方案

LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

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