所有图片(1)
About This Item
经验公式（希尔记法）:
C10H12Li3N5O10P2S
CAS号:
分子量:
477.07
Beilstein:
8181243
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
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![鸟苷5′-[β,γ-亚氨基]三磷酸 三钠盐 水合物 ≥85% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/204/494/05808804-1ca7-44bf-b6c5-d4934dc7cb85/640/05808804-1ca7-44bf-b6c5-d4934dc7cb85.png)
质量水平
方案
≥85% (HPLC)
表单
powder
颜色
white
溶解性
H2O: 20 mg/mL (Solutions are very unstable; prepare immediately prior to use.)
运输
dry ice
储存温度
−20°C
SMILES字符串
[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1
InChI
1S/C10H15N5O10P2S.3Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(24-9)1-23-26(19,20)25-27(21,22)28;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H2,21,22,28)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1
InChI key
LMCWQGPJYZRMKU-CYCLDIHTSA-K
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相关类别
应用
鸟苷5′-[β-硫代]二磷酸三锂盐已作为G蛋白激活抑制剂，用于研究其对袋细胞神经元中的乙酰胆碱电流的影响。它还用于研究其对胆碱能依赖性平台期电位的影响。
生化/生理作用
鸟苷5′-[β-硫代]二磷酸是鸟苷的不可水解类似物，可用作G蛋白激活抑制剂。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
联系
不可水解的 GDP 类似物
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
E Oberdisse et al.
Biochemical and biophysical research communications, 144(3), 1188-1196 (1987-05-14)
Guanosine 5'-O-thiotriphosphate (GTP gamma S) and thrombin stimulate the activity of phospholipase C in platelets that have been permeabilized with saponin and whose inositol phospholipids have been prelabeled with [3H]inositol. Ca2+ has opposite effects on the formation of [3H]inositol phosphates
D D Fraser et al.
Journal of neurophysiology, 85(3), 1197-1205 (2001-03-15)
We previously identified cholinergic-dependent plateau potentials (PPs) in CA1 pyramidal neurons that were intrinsically generated by interplay between voltage-gated calcium entry and a Ca(2+)-activated nonselective cation conductance. In the present study, we examined both the second-messenger pathway and the role
E Y Moon et al.
Life sciences, 86(17-18), 683-690 (2010-03-03)
We evaluated Gi-protein inhibitor, guanosine 5'-O-(2-thiodiphosphate)(GOT)-induced senescence-associated(SA)-beta-galactosidase(Gal) positive cell formation to determine if it occurred through phosphorylation of cyclic AMP-dependent response element binding protein (CREB). IMR-90 human lung fibroblast cells were used. SA-beta-Gal positive cells and senescence-associated heterochromatic foci (SAHF)
A K H Tam et al.
Neuroscience, 179, 41-55 (2011-02-01)
Targeting signalling molecules to ion channels can expedite regulation and assure the proper transition of changes to excitability. In the bag cell neurons of Aplysia, single-channel studies of excised patches have revealed that protein kinase C (PKC) gates a non-selective
R J Ho et al.
Archives of biochemistry and biophysics, 251(1), 148-155 (1986-11-15)
Forskolin-activated adenylate cyclases (AC) in intact membranes, solubilized with Lubrol or eluted following adsorption on a forskolin-Sepharose column, were examined for inhibition by GDP and GDP beta S. AC in intact membranes of rat or rabbit adipocytes was activated by
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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