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Merck
CN
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文件

G7132

Sigma-Aldrich

甘胆酸钠 水合物

≥95% (TLC)

别名:

3α,7α,12α-三羟基-5β-胆烷-24-酸 N-（羧甲基）酰胺 钠盐, N-（3α,7α,12α-三羟基-24-氧代胆碱-24-基）甘氨酸 钠盐, 甘氨胆酸 钠盐, 甘氨胆酸 钠盐 水合物

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About This Item

线性分子式:
C26H42NO6Na · xH2O
CAS号:
338950-81-5
分子量:
487.60 (anhydrous basis)
Beilstein:
3854517
EC 号:
212-730-9
MDL编号:
MFCD09037360
UNSPSC代码:
12161900
PubChem化学物质编号:
24895292
NACRES:
NA.25

描述

anionic

质量水平

200

检测方案

≥95% (TLC)

分子量

micellar avg mol wt 900(lit.)

聚集数

1.9

CMC

13 mM (20-25°C)(lit.)

mp

210-215 °C (subl.) (lit.)

SMILES字符串

[Na+].[H]O[H].[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@H](CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCC([O-])=O

InChI

1S/C26H43NO6.Na.H2O/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);;1H2/q;+1;/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-;;/m1../s1

InChI key

YWROUPFMHKARON-HJRQWJHVSA-M

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相关类别

一般描述

甘胆酸钠水合物是一种共轭胆盐和离子型生物洗涤剂。

应用

在一项研究中，使用甘胆酸钠水合物通过荧光法和酶法评估血清总胆汁酸。 也用于研究其对睾酮胶束形成和增溶的影响。

生化/生理作用

胆盐

制备说明

该产品由天然胆酸（产品号C1129）合成制备而成。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Monalisa Mohapatra et al.
Langmuir : the ACS journal of surfaces and colloids, 27(22), 13461-13467 (2011-10-07)
The interaction of submicellar concentrations of various physiologically important unconjugated [sodium deoxycholate (NaDC), sodium cholate (NaC)] and conjugated [sodium glycodeoxycholate (NaGDC), sodium glycocholate (NaGC), sodium taurodeoxycholate (NaTDC), sodium taurocholate (NaTC)] bile salts with dipalmitoylphosphatidylcholine (DPPC) and dimyristoylphosphatidylcholine (DMPC) small unilamellar
Feilong Sun et al.
Colloids and surfaces. B, Biointerfaces, 170, 521-528 (2018-07-04)
Poorly soluble vitamin K cannot be absorbed by patients suffering from cholestasis due to extremely low level of bile salts in the intestine. A formulation of vitamin K including glycocholic acid (i.e. Konakion® MM), does not increase bioavailability because it
Mari Araki et al.
Journal of biochemistry, 160(5), 269-279 (2016-11-02)
DDHD2 has been reported to exhibit phospholipase A
Micelle formation and testosterone solubilization by sodium glycocholate.
L Martis et al.
Journal of pharmaceutical sciences, 61(11), 1757-1761 (1972-11-01)
Enrique Joffre et al.
Scientific reports, 9(1), 108-108 (2019-01-16)
Pathogenic bacteria use specific host factors to modulate virulence and stress responses during infection. We found previously that the host factor bile and the bile component glyco-conjugated cholate (NaGCH, sodium glycocholate) upregulate the colonization factor CS5 in enterotoxigenic Escherichia coli
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