G6129
鸟苷-3′,5′-环一磷酸 钠盐
≥99% (HPLC), Cyclic nucleotide, powder
别名:
3′，5′-环GMP 单钠盐, 3′，5′-环磷酸鸟苷钠, cGMP, 环GMP, 鸟苷-3′,5′-环磷酸酯 单钠盐
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关于此项目
经验公式（希尔记法）:
C10H11N5NaO7P
化学文摘社编号:
分子量:
367.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
255-056-0
MDL number:
Beilstein/REAXYS Number:
6467425
产品名称
鸟苷-3′,5′-环一磷酸 钠盐, ≥99% (HPLC), powder
Quality Level
assay
≥99% (HPLC)
form
powder
color
white
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C(=O)N1
InChI
1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChI key
KMPIYXNEROUNOG-GWTDSMLYSA-M
Biochem/physiol Actions
作为重要的第二信使，cGMP是细胞外信号（例如一氧化氮和利尿钠肽）的主要细胞内介质。环状GMP可与三种类型的细胞内受体蛋白相互作用：cGMP依赖性蛋白激酶、cGMP调节的通道、以及cGMP调节的环核苷酸磷酸二酯酶。cGMP水平在体内升高的主要作用是刺激cGMP依赖性蛋白激酶（PKG）。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
G Colamartino et al.
The Journal of physiology, 440, 189-206 (1991-01-01)
1. Blockage and permeation of divalent cations through channels activated by guanosine 3',5'-cyclic monophosphate (cyclic GMP) were studied in membrane patches excised from retinal rods of the tiger salamander Ambystoma tigrinum by rapidly changing the ionic medium bathing the intracellular
C Picco et al.
The Journal of physiology, 460, 741-758 (1993-01-01)
1. The permeability of the channel activated by guanosine 3',5'-cyclic monophosphate (cGMP) to many organic monovalent cations was determined by recording macroscopic currents in excised inside-out patches of plasma membrane from isolated retinal rod outer segments of the tiger salamander.
You-Lin Tain et al.
Biology of reproduction, 92(1), 7-7 (2014-11-15)
Nitric oxide (NO) deficiency induced by the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine-methyl ester (L-NAME) resulted in hypertension. L-citrulline (CIT) can be converted to L-arginine to generate NO. We examined whether maternal CIT supplementation can prevent L-NAME-induced programmed hypertension. Pregnant Sprague-Dawley
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G6129-500MG | 04061832898056 |
| G6129-25MG | 04061833638859 |
| G6129-1G | 04061826682722 |
| G6129-100MG | 04061832898032 |
| G6129-250MG | 04061832898049 |