推荐产品
质量水平
方案
≥95% (TLC)
表单
solution
包装
vial of 200 μg
浓度
~1 mg/mL in methanol: NH4OH (7:3)
储存温度
−20°C
SMILES字符串
C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
InChI
1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+
InChI key
OINNEUNVOZHBOX-QIRCYJPOSA-N
相关类别
应用
香叶基香叶基焦磷酸盐已用于：
- 制备用于Rab GGTase测定的2.5X反应缓冲液
- 添加到培养物中，进一步驱动Hmg2降解
- 用作体外酶促测定鉴定异戊二烯基转移酶时的底物
- 逆转洛伐他汀作用，还用于检验GGPP在研究中的潜在作用，以评估在体外共培养血管生成模型中，洛伐他汀对黑素瘤细胞系的作用
生化/生理作用
来自细胞内甲羟戊酸途径的类异戊二烯可用于几种低分子量G蛋白（包括Ras）的异戊烯化。 萜烯生物合成中间体。
香叶基香叶基焦磷酸酶（GGPP）是一种主要的酶，参与叶绿体的次级代谢。GGPP合酶在类萜生物合成中起关键作用。香叶基香叶基焦磷酸酶介导的蛋白质香叶基香叶基化参与心室的发育。它还可充当特定阶段的信号，调节妊娠中期心脏细胞结构的形成。
特点和优势
该化合物是环核苷酸研究的推荐产品。点击此处，了解更多精选环核苷酸产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
51.8 °F - closed cup
闪点(°C)
11 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sergi Guixé-Muntet et al.
Journal of hepatology, 66(1), 86-94 (2016-08-23)
The transcription factor Krüppel-like factor 2 (KLF2), inducible by simvastatin, confers endothelial vasoprotection. Considering recent data suggesting activation of autophagy by statins, we aimed to: 1) characterize the relationship between autophagy and KLF2 in the endothelium, 2) assess this relationship
Hirokazu Sakamoto et al.
The Journal of eukaryotic microbiology, 64(4), 440-446 (2016-11-05)
Some organisms have retained plastids even after they have lost the ability to photosynthesize. Several studies of nonphotosynthetic plastids in apicomplexan parasites have shown that the isopentenyl pyrophosphate biosynthesis pathway in the organelle is essential for their survival. A phytohormone
Action of Lovastatin (Mevinolin) on an in vitro model of angiogenesis and its co-culture with malignant melanoma cell lines
Depasquale I and Wheatley D N
Cancer Cell International, 6(1), 9-9 (2006)
Isoprenoid biosynthesis in the diatom Haslea ostrearia
Athanasakoglou A, et al.
The New phytologist (2018)
Christopher I Keeling et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(47), 18838-18843 (2013-10-30)
The mountain pine beetle (Dendroctonus ponderosae Hopkins) is the most destructive pest of western North American pine forests. Adult males produce frontalin, an eight-carbon antiaggregation pheromone, via the mevalonate pathway, as part of several pheromones that initiate and modulate the
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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