生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
K-87, monoclonal
分子量
antigen 67 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:20,000 (with antigen-retrieval step)
western blot: 1:500-1:20,000 using mouse brain extract
同位素/亚型
IgG1κ
UniProt登记号
运输
dry ice
储存温度
−70°C
靶向翻译后修饰
unmodified
基因信息
human ... GAD1(2571)
mouse ... Gad1(14415)
rat ... Gad1(24379)
一般描述
谷氨酸脱羧酶67（GAD67）由基因谷氨酸脱羧酶1（GAD1）编码。GAD1基因位于人染色体2q31.1。GAD67位于树突和细胞体。
特异性
与 GAD67 特异性反应。不与 GAD65 发生交叉反应。
免疫原
来自小鼠 GAD67 的合成肽（氨基酸 87-106）。
该肽与 GAD65 不具有同源性。
应用
小鼠抗谷氨酸脱羧酶67（GAD67）单克隆抗体已被用于：
- 免疫组织荧光
- 蛋白质印迹
- 免疫组织化学。
抗谷氨酸脱羧酶 67（GAD67）单克隆抗体适用于免疫印迹、免疫印迹（1：500-1：20,000 稀释，小鼠脑提取物）和免疫组化（1：500-1：20,000 稀释，小鼠脑切片）。
生化/生理作用
谷氨酸脱羧酶67（GAD67）涉及 γ-氨基丁酸 (GABA)的生产，氨基丁酸是中枢神经系统 (CNS)中的一种抑制性神经递质。GAD67缺乏会导致精神病、精神分裂和双向情感障碍。
外形
在含有 0.01％ 叠氮化钠的磷酸盐缓冲盐水中的溶液。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Mitsuhiro Tsuboi et al.
Cancer medicine, 8(9), 4189-4199 (2019-06-18)
In a previous genome-wide screening, we identified hypermethylated CpG islands around glutamate decarboxylase 1 (GAD1) in lung adenocarcinoma (LADC). In this study, we aimed to investigate the methylation and expression status of GAD1 and its prognostic value in patients with
Minjung Kim et al.
PloS one, 7(2), e32043-e32043 (2012-03-01)
The analysis of co-localized protein expression in a tissue section is often conducted with immunofluorescence histochemical staining which is typically visualized in localized regions. On the other hand, chromogenic immunohistochemical staining, in general, is not suitable for the detection of
Ying Chen et al.
Neuropharmacology, 60(7-8), 1075-1087 (2010-09-28)
GAD67 corresponds to one of two enzymes that decarboxylates glutamate to produce γ-aminobutyric acid, the main inhibitory neurotransmitter in the mammalian central nervous system, hence defining the cellular phenotype of a diverse set of inhibitory interneurons of the brain. Reduced
A Guidotti et al.
Archives of general psychiatry, 57(11), 1061-1069 (2000-11-14)
Reelin (RELN) is a glycoprotein secreted preferentially by cortical gamma-aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin receptors located on dendritic spines of pyramidal neurons or on GABAergic interneurons of layers III through V expressing the
Schahram Akbarian et al.
Brain research reviews, 52(2), 293-304 (2006-06-09)
The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with schizophrenia and related disorders, including autism and bipolar illness. The predominant finding
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