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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
secondary antibodies
克隆
GT-34, monoclonal
包含
15 mM sodium azide
种属反应性
sheep, goat, bovine
请勿与下列物质发生反应
rat, canine, mouse, rabbit, guinea pig, chicken, horse, pig, feline, human
技术
indirect ELISA: 1:10,000-1:20,000
同位素/亚型
IgG1
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
相关类别
一般描述
抗体与位于山羊 IgG1 和 IgG2 重链上的表位反应。
IgG is the main type of antibody in human serum, secreted by the B cells. It is found in blood. IgG consists of four polypeptide chains, made of two identical 50 kDa γ heavy (H) chains and two identical 25 kDa κ or λ light (L) chains, which are linked by inter-chain disulfide bonds. IgG contains four isotypes IgG1, IgG2, IgG3 and IgG4.
特异性
Monoclonal Anti-Goat/Sheep IgG recognizes an epitope located on the heavy chain of goat IgG1 and IgG2. The antibody shows strong cross-reactivity with sheep IgG and weak cross-reactivity with bovine IgG. No cross-reactivity is observed with IgG derived from human, guinea pig, rat, horse, dog, chicken, pig, mouse, rabbit, or cat.
应用
Monoclonal Anti-Goat/Sheep IgG antibody produced in mouse has been used in:
- enzyme linked immunosorbent assay (ELISA)
- immunoblotting
- immunoprecipitation
- immunoelectrophoresis
生化/生理作用
IgG stimulates the classical pathway of the complement system. It neutralizes virus particles and toxins. IgG plays a crucial role in antibody-dependent cell-mediated cytotoxicity (ADCC). IgG might be associated with allergy. It has the longest serum half life.
外形
The product is provided as ascites fluid with 0.1% sodium azide as preservative.
储存及稳定性
For continuous use, store at 2–8 °C for up to one month. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Tom N McNeilly et al.
Veterinary research, 44, 70-70 (2013-08-24)
Teladorsagia circumcincta is an important pathogenic nematode of sheep. It has been demonstrated previously that stimulation of murine T lymphocytes with excretory-secretory (ES) products derived from fourth stage larvae of T. circumcincta (Tci-L4-ES) results in de novo expression of Foxp3
Seasonal variations of phagocytic response, immunoglobulin G (IgG) and plasma cortisol levels in Dhofari goats
Al-Busaidi R, et al.
Small Ruminant Research, 79(2-3), 118-123 (2008)
Guillaume Sallé et al.
International journal for parasitology, 48(5), 395-402 (2018-03-15)
Some nematode species are economically important parasites of livestock, while others are important human pathogens causing some of the most important neglected tropical diseases. In both humans and animals, anthelmintic drug administration is the main control strategy, but the emergence
Reconstitution of Microtubule Nucleation InA Vitro Reveals Novel Roles for Mzt1.
Leong, et al.
Current Biology, 33, 1864-1864 (2023)
Brett Roberts et al.
Veterinary research, 44(1), 111-111 (2013-12-03)
With the problem of parasitic nematode drug resistance increasing, vaccine development offers an alternative sustainable control approach. For some parasitic nematodes, native extracts enriched for specific proteins are highly protective. However, recombinant forms of these proteins have failed to replicate
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