G2253
L-谷氨酸& # 947;-单羟基己酸酯
≥97% (TLC)
别名:
-5--羟基谷氨酰胺, L-& # 947;-谷氨酰异羟肟酸
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关于此项目
经验公式（希尔记法）:
C5H10N2O4
化学文摘社编号:
分子量:
162.14
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
产品名称
L-谷氨酸& # 947;-单羟基己酸酯,
SMILES string
NC(CCC(=O)NO)C(O)=O
InChI
1S/C5H10N2O4/c6-3(5(9)10)1-2-4(8)7-11/h3,11H,1-2,6H2,(H,7,8)(H,9,10)
InChI key
YVGZXTQJQNXIAU-UHFFFAOYSA-N
assay
≥97% (TLC)
form
powder
color
white to off-white
application(s)
detection
storage temp.
−20°C
Quality Level
Application
左旋谷氨酸γ-单异羟肟酸已用作计算谷氨酰胺转胺酶(TGase)活性的标准品。
Biochem/physiol Actions
L-谷氨酸& # 947；-单羟基肟酸盐[L-谷氨酸（γ）HXM]用作钒配体，增强钒代谢活性。L-Glu（γ）HXM也用作大肠杆菌 大肠杆菌天冬酰胺合成酶B的底物和作为ATP依赖性的大肠杆菌γ-谷氨酰半胱氨酸合成酶的不可逆抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
N Seiler et al.
Neurochemical research, 15(3), 301-305 (1990-03-01)
The method for the assay of glutamine synthetase (GlnS) relies on the gamma-glutamyl transferase reaction, i.e. the formation of glutamyl-gamma-hydroxamate from glutamine and hydroxylamine, and the chromatographic separation of the reaction product from the reactants. The method is not only
Inhibition of malate-aspartate shuttle by the antitumor drug L-glutamic acid gamma-monohydroxamate in L1210 leukemia cells.
N Thomasset et al.
International journal of cancer, 51(2), 329-332 (1992-05-08)
N Thomasset et al.
Anticancer research, 13(5A), 1393-1398 (1993-09-01)
We have previously shown that L-glutamic acid gamma-monohydroxamate (GAH) exhibits an antitumor activity, both in vitro and in vivo. In this report we explore the selective cytotoxicity of GAH in vitro by comparing the survival of tumor and normal cells.
I Goldwaser et al.
The Journal of biological chemistry, 274(37), 26617-26624 (1999-09-03)
We report that the vanadium ligand L-Glu(gamma)HXM potentiates the capacity of free vanadium ions to activate glucose uptake and glucose metabolism in rat adipocytes in vitro (by 4-5-fold) and to lower blood glucose levels in hyperglycemic rats in vivo (by
M Katoh et al.
Bioscience, biotechnology, and biochemistry, 62(7), 1455-1457 (1998-08-28)
Incubation of Escherichia coli gamma-glutamylcysteine synthetase with L-glutamic acid gamma-monohydroxamate and ATP caused slow but irreversible inhibition of the enzyme, and more than 90% activity was lost in three days. The enzyme was not inactivated when ATP was absent or
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