所有图片(1)
About This Item
经验公式（希尔记法）:
C12H21N3O6S
CAS号:
分子量:
335.38
MDL编号:
UNSPSC代码:
12161504
PubChem化学物质编号:
NACRES:
NA.26
product name
还原型谷胱甘肽乙酯, ≥90% (TLC)
质量水平
检测方案
≥90% (TLC)
形式
powder
颜色
white to off-white
储存温度
−20°C
SMILES字符串
CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
InChI
1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
InChI key
JKRODHBGNBKZLE-YUMQZZPRSA-N
Amino Acid Sequence
Glu-Cys-Gly-OEt
应用
还原型谷胱甘肽乙酯已被用于：
- 提高小鼠成纤维细胞 L929 细胞内谷胱甘肽水平
- 作为 果翅目昆虫 (Sf) 9 细胞的培养基补充
- 以评价其对脊髓损伤后脂质过氧化作用
生化/生理作用
谷胱甘肽乙酯（还原型）可通过抑制Melan-A细胞中的酪氨酸酶活性来抑制黑色素合成。它的抗黑色素生成功能可用于治疗皮肤色素沉着过度性疾病。从胰腺分离胰岛时，添加谷胱甘肽乙酯(GEE)可减少活性氧物质生成和细胞凋亡。
还原型谷胱甘肽乙酯 (GSH—MEE) 是 GSH 的膜/脂质渗透性衍生物，可用于部分补充细胞内遭受半胱氨酸和/或 GSH 耗竭的 GSH 供应。GSH-MEE 被细胞内酯酶水解释放 GSH，从而增加细胞内 GSH 的浓度。 防止动物细胞中对乙酰氨基酚的毒性作用。保护人体淋巴细胞和皮肤成纤维细胞免受辐射造成的损伤。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
M E Anderson et al.
Analytical biochemistry, 183(1), 16-20 (1989-11-15)
Glutathione monoesters in which the glycine carboxyl group is esterified are effective cellular glutathione delivery agents because they are readily transported into cells and are deesterified intracellularly. In contrast, glutathione itself is not effectively transported into cells. Detailed procedures are
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Rissone A
The Journal of Experimental Medicine, 212(8), 1185-1202 (2015)
Epigallocatechin-3-gallate inhibits growth of activated hepatic stellate cells by enhancing the capacity of glutathione synthesis.
Fu Y
Molecular Pharmacology, 73(5), 1465-1473 (2008)
I Rahman et al.
Biochemical pharmacology, 62(6), 787-794 (2001-09-12)
The airway epithelium is injured by oxidants inhaled as atmospheric pollutants or produced during inflammatory responses. We studied the effect of modulating the antioxidant intracellular glutathione, both using thiol compounds and by the adaptive effect of hyperoxia, on oxidant-induced injury
Glutathione monoethyl ester improves functional recovery, enhances neuron survival, and stabilizes spinal cord blood flow after spinal cord injury in rats
Guizar-Sahagun G, et al.
Neuroscience, 130(3), 639-649 (2005)
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