product name
聚-L-γ-谷氨酸 钠盐,
形式
powder
质量水平
分子量
≥750,000
技术
drug transporter assay: suitable
颜色
white to off-white
应用
cell analysis
储存温度
−20°C
应用
高分子量聚-γ-谷氨酸（γPGA）被证明可以在C57BL/6小鼠中增加NK细胞介导的细胞毒性水平以及 INF-γ分泌。 已经评估了可生物降解的γ-PGA纳米颗粒作为抗原递送载体 以及递送流感病毒血凝素（HA）疫苗的应用。 γ-PGA的其他生命科学应用包括用于可生物降解的纤维和纳米纤维片、水凝胶和冷冻保护剂。
其他说明
高分子量聚-γ-谷氨酸是一种谷氨酸聚合物，由α-氨基和γ-羧基之间的酰胺键连接。 γ-PGA是由芽孢杆菌发酵产生的。该亚基主要是L-异构体。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Shigefumi Okamoto et al.
Vaccine, 27(42), 5896-5905 (2009-08-04)
Adding poly(gamma-glutamic acid) nano-particles (gamma-PGA-NPs), a safe, natural material, to subcutaneous immunization with influenza virus hemagglutinin (HA) vaccine increases the protective immune responses against influenza virus in mice. Here, we examined whether intranasal administration of the HA vaccine with gamma-PGA-NPs
Preparation and evaluation of poly(γ-glutamic acid)-based anti-adhesion membranes.
Kim, Y.-A., et al.
Key Engineering Materials, 342, 225-225 (2007)
The utility of poly(γ-glutamic acid) nanoparticles as antigen delivery carriers in dendritic cell-based cancer immunotherapy.
Matsuo, K., et al.
Biological & Pharmaceutical Bulletin, 33, 2007-2007 (2010)
Ilaria Massaiu et al.
Microbial cell factories, 18(1), 3-3 (2019-01-11)
Genome-scale metabolic models (GEMs) allow predicting metabolic phenotypes from limited data on uptake and secretion fluxes by defining the space of all the feasible solutions and excluding physio-chemically and biologically unfeasible behaviors. The integration of additional biological information in genome-scale models
Haryoung Poo et al.
Chemistry & biodiversity, 7(6), 1555-1562 (2010-06-22)
Ultra-high-molecular-weight poly-gamma-glutamic acid (gamma-PGA) is a most promising biodegradable polymer that is produced by Bacillus subtilis (chungkookjang). Attractive properties of gamma-PGA are that it is water soluble, anionic, biodegradable, and edible. Development of gamma-PGA has pursued in terms of cosmetics/skin
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