G1049
聚-L-γ-谷氨酸 钠盐
suitable for drug transporter assays, Mol wt ≥750,000
别名:
γ-PGA
产品名称
聚-L-γ-谷氨酸 钠盐,
form
powder
mol wt
≥750,000
technique(s)
drug transporter assay: suitable
color
white to off-white
application(s)
cell analysis
storage temp.
−20°C
Quality Level
Application
高分子量聚-γ-谷氨酸（γPGA）被证明可以在C57BL/6小鼠中增加NK细胞介导的细胞毒性水平以及 INF-γ分泌。 已经评估了可生物降解的γ-PGA纳米颗粒作为抗原递送载体 以及递送流感病毒血凝素（HA）疫苗的应用。 γ-PGA的其他生命科学应用包括用于可生物降解的纤维和纳米纤维片、水凝胶和冷冻保护剂。
Other Notes
高分子量聚-γ-谷氨酸是一种谷氨酸聚合物，由α-氨基和γ-羧基之间的酰胺键连接。 γ-PGA是由芽孢杆菌发酵产生的。该亚基主要是L-异构体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Tae Woo Kim et al.
Journal of immunology (Baltimore, Md. : 1950), 179(2), 775-780 (2007-07-10)
We analyzed the in vivo tumor regression activity of high molecular mass poly-gamma-glutamate (gamma-PGA) from Bacillus subtilis sups. chungkookjang. C57BL/6 mice were orally administered 10-, 100-, or 2000-kDa gamma-PGA or beta-glucan (positive control), and antitumor immunity was examined. Our results
I L Shih et al.
Bioresource technology, 79(3), 207-225 (2001-08-14)
This review article deals with the chemistry and biosynthesis of poly-(gamma-glutamic acid) (gamma-PGA) produced by various strains of Bacillus. Potential applications of gamma-PGA as thickener, cryoprotectant, humectant, drug carrier, biological adhesive, flocculant, or heavy metal absorbent, etc. with biodegradability in
Preparation and evaluation of poly(γ-glutamic acid)-based anti-adhesion membranes.
Kim, Y.-A., et al.
Key Engineering Materials, 342, 225-225 (2007)
The utility of poly(γ-glutamic acid) nanoparticles as antigen delivery carriers in dendritic cell-based cancer immunotherapy.
Matsuo, K., et al.
Biological & Pharmaceutical Bulletin, 33, 2007-2007 (2010)
Ilaria Massaiu et al.
Microbial cell factories, 18(1), 3-3 (2019-01-11)
Genome-scale metabolic models (GEMs) allow predicting metabolic phenotypes from limited data on uptake and secretion fluxes by defining the space of all the feasible solutions and excluding physio-chemically and biologically unfeasible behaviors. The integration of additional biological information in genome-scale models
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