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Merck
CN

G0903

γ-Glu-Cys

≥80% (HPLC), suitable for ligand binding assays

别名:

γ-L-谷氨酰基-L半胱氨酸, 去甘氨酸-谷胱甘肽的还原形式

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关于此项目

经验公式(希尔记法):
C8H14N2O5S
化学文摘社编号:
分子量:
250.27
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
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产品名称

γ-Glu-Cys, ≥80% (HPLC)

质量水平

方案

≥80% (HPLC)

表单

powder

组成

Peptide content, ≥60% elemental analysis

技术

ligand binding assay: suitable

颜色

white to off-white

储存温度

−20°C

SMILES字符串

N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O

InChI

1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1

InChI key

RITKHVBHSGLULN-WHFBIAKZSA-N

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Amino Acid Sequence

Glu-Cys

应用

γ-Glu-Cys可用于研究谷胱甘肽合成酶的活性位点和动力学。它也被用于从拟南芥 组织中提取和量化低分子量硫醇。

生化/生理作用

γ-L-谷氨酰基-L-半胱氨酸(γ-Glu-Cys)是用于通过谷胱甘肽合成酶生物合成L-谷胱甘肽的底物。γ-Glu-Cys通过裂解谷胱甘肽的Cys-Gly肽键而产生。它对植物螯合素的形成也是必需的,植物螯合素是富含半胱氨酸的硫醇反应性肽。

外形

从0.1%TFA中冻干获得。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jan Stout et al.
Journal of molecular biology, 416(4), 486-494 (2012-01-10)
Glutathione is an intracellular redox-active tripeptide thiol with a central role in cellular physiology across all kingdoms of life. Glutathione biosynthesis has been traditionally viewed as a conserved process relying on the sequential activity of two separate ligases, but recently
Chava B Pocernich et al.
Biochimica et biophysica acta, 1822(5), 625-630 (2011-10-22)
Oxidative stress has been associated with the onset and progression of mild cognitive impairment (MCI) and Alzheimer disease (AD). AD and MCI brain and plasma display extensive oxidative stress as indexed by protein oxidation, lipid peroxidation, free radical formation, DNA
A Andersson et al.
Clinical chemistry, 38(7), 1311-1315 (1992-07-01)
The concentration of free and total homocysteine in plasma increases in time if blood is stored uncentrifuged after sampling. The increase is temperature dependent and the maximal increase in total plasma homocysteine at 37 degrees C was 3.0 mumol.L-1.h-1. Even
Quantification of Low Molecular Weight Thiols in Arabidopsis
Ziqing Miao
Bio-protocol, 6(1) (2016)
Naser A. Anjum, Sarvajeet Singh Gill, Ritu Gill
Plant Adaptation to Environmental Change: Significance of Amino Acids and their Derivatives (2014)

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