推荐产品
生物来源
bacterial (Corynebacterium sp)
质量水平
检测方案
≥90%
形式
lyophilized powder
包装
vial of ~1 mg ATP
储存温度
−20°C
SMILES字符串
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O
InChI
1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
InChI key
NTBQNWBHIXNPRU-MSQVLRTGSA-L
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相关类别
应用
腺苷5′-三磷酸盐(ATP)二钠盐水合物用作:
- 生物发光法测定ATP的标准物
- 激酶缓冲液,以评估死亡相关蛋白激酶(DAPK2)与14-3-3-β之间的相互作用
- ATP比色测定的标准
生化/生理作用
5′-三磷酸腺苷通过清除TNF-α的分泌和促进白介素-10的分泌,发挥对炎症反应的抑制作用。
P2 嘌呤能激动剂;增加 Ca2+-激活的 K+ 通道的活性;ATP-依赖酶系统的底物
腺苷5′-三磷酸(ATP)是存在于生命系统中的一种核苷三磷酸。它控制着各种生物过程,如葡萄糖代谢、肌肉收缩和神经传递等。除此之外,ATP还是细胞重要的能量来源。ATP的应用对非小细胞肺癌的治疗可能有用。
数量
每小瓶含 ~1.2mg Na2ATP • 3H2O,相当于 ~1.0mg ATP (2.0μmol)。标签上印有实际含量。
制备说明
制备过程基本无钒。
WGK
WGK 2
个人防护装备
Eyeshields, Gloves, type N95 (US)
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In vitro studies suggest that extracellular nucleotides and nucleosides may be important regulators of inflammatory and immune responses. Most studies with adenosine 5'-triphosphate (ATP) have been performed in cell lines, which are remote from the human situation. The purpose of
Journal of medicinal chemistry, 50(6), 1166-1176 (2007-02-17)
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Journal of medicinal chemistry, 53(24), 8485-8497 (2010-11-26)
Nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyze extracellular nucleotides and dinucleotides and thus control purinergic signaling. Enhanced NPP activity is implicated in health disorders such as osteoarthritis and cancer. We designed novel diadenosine polyphosphonate derivatives as potential NPP inhibitors. Analogues 1-4 bear a
Journal of medicinal chemistry, 49(15), 4606-4615 (2006-07-21)
17-Allylamino-17-demethoxygeldanamycin (17-AAG)1 is a semisynthetic inhibitor of the 90 kDa heat shock protein (Hsp90) currently in clinical trials for the treatment of cancer. However, 17-AAG faces challenging formulation issues due to its poor solubility. Here we report the synthesis and
实验方案
HPLC separation of nucleotide salts ensures high purity for biochemical studies and research applications.
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