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Merck
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安全信息

F8174

Sigma-Aldrich

Follicle Stimulating Hormone from sheep pituitary

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别名:
FSH
CAS号:
9002-68-0
MDL编号:
MFCD00131099
UNSPSC代码:
51111800
eCl@ss:
42020504

质量水平

100

UniProt登记号

P01227
P23945

储存温度

2-8°C

基因信息

human ... FSHR(2492)
sheep ... FSHB(443387)

一般描述

FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where α subunit has resemblance to LH (luteinizing hormone), hCG (human chorionic gonadotropin) and TSH (thyrotropin-releasing hormone), which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.

应用

Follicle stimulating hormone from sheep pituitary has been used for-
  • the in vitro maturation of bovine ovaries
  • the hormonal treatment of Sertoli cells
  • the intraperitoneal hormone treatment of male lizards
  • the intramuscular hormone treatment of American alligator (Alligator mississippiensis)
  • use in medium used for the maturation of bovine cumulus-oocyte complexes (COCs)

生化/生理作用

FSH (follicle stimulating hormone) in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In Caucasian population, certain polymorphisms in FSHR gene are more commonly found in patients with polycystic ovary syndrome (PCOS).
The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.

其他说明

Two-chain glycoprotein hormone

分析说明

50 units per vial by the Steelman-Pohley assay using NIH-FSH-S1 reference standard.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Do you have information on the solution stability of Follicle Stimulating Hormone (FSH) from pituitary?

    For information on the solution stability of FSH (and much more), refer to Chem. Soc. Rev., 2(4), 355-395 (1973).From page 369:  "The stabilities of the most highly purified preparations of certain hormonal glycoproteins have presented some problems, e.g. follicle-stimulating hormone preparations are often found to be stable in frozen solution but lose activity dramatically on concentration and freeze drying." Based on that information, we would recommend that if you need to freeze solutions of FSH, you should flash-freeze the solution (using either liquid nitrogen or a dry ice-alcohol bath), and store the solution in the ultra-cold (-70 or -80°C) freezer. Since FSH does have some solution stability concerns, simply placing the solution in a -20°C freezer without first flash-freezing may reduce the activity.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Levent Keskintepe et al.
Biology of reproduction, 67(2), 409-415 (2002-07-24)
Pronuclear formation, and the chromosomal constitution and developmental capacity of bovine zygotes formed by intracytoplasmic sperm injection with freeze-dried (lyophilized) spermatozoa were evaluated. Frozen-thawed spermatozoa were selected, freeze-dried, and stored at 4 degrees C until use. After 22-24 h of
Feng Wang et al.
Fertility and sterility, 101(2), 577-586 (2013-12-10)
To analyze the potential beneficial effects and mechanisms of action of resveratrol on the maturation of bovine oocytes that were incubated in different concentrations of resveratrol (0.1, 1.0, or 10.0 μM) as germinal vesicle-stage oocytes. In vitro prospective study. University
Suzanne C Mills et al.
The American naturalist, 171(3), 339-357 (2008-01-19)
Sexual selection predicts that trade-offs maintain trait variation in alternative reproductive strategies. Experiments often focus on testosterone (T), but the gonadotropins follicle-stimulating hormone and luteinizing hormone may provide a clearer understanding of the pleiotropic relationships among traits. We assess the
Thomas Saether et al.
Biology of reproduction, 69(1), 117-124 (2003-02-28)
In mammalian cells, essential polyunsaturated fatty acids (PUFAs) are converted to longer PUFAs by alternating steps of elongation and desaturation. In contrast to other PUFA-rich tissues, the testis is continuously drained of these fatty acids as spermatozoa are transported to
Brandon C Moore et al.
Molecular and cellular endocrinology, 354(1-2), 111-120 (2011-11-09)
Developing organisms interpret and integrate environmental signals to produce adaptive phenotypes that are prospectively suited for probable demands in later life. This plasticity can be disrupted when embryos are impacted by exogenous contaminants, such as environmental pollutants, producing potentially deleterious
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