869001-M
卵泡刺激素，来源于人垂体，碘化级
Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.
别名:
卵泡刺激素，来源于人垂体，碘化级, Follitropin, hFSH
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Biological source:
human pituitary glands
Form:
lyophilized solid
Assay:
≥90%
产品名称
卵泡刺激素，来源于人垂体，碘化级, Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.
biological source
human pituitary glands
description
Merck USA index - 14, 4223
sterility
non-sterile
product line
Calbiochem®
assay
≥90%
form
lyophilized solid
specific activity
≥2000 IU/mg
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
≤0.1% hCG
≤0.5% hLH, hTSH
pI
4.1
solubility
PBS: soluble
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
卵泡刺激素（FSH）参与哺乳动物的生殖调节。它通过一种称为卵泡刺激素受体（FSHR）的G蛋白偶联受体发挥作用该受体位于卵巢颗粒细胞和睾丸的支持细胞上。FSH在雌性卵泡成熟中发挥作用，并通过激活雄性支持细胞增殖来支持精子形成。FSH与其受体FSH-R的相互作用可激活G-蛋白偶联受体/环腺苷单磷酸（cAMP）/蛋白激酶A通路，以传递细胞内信号。
Disclaimer
毒性：致癌/致畸（D）
General description
卵泡刺激素（FSH）属于糖蛋白激素家族。它在存在于垂体中的促性腺激素合成。FSH含有非共价结合的α-和β-亚基，是一种富含二硫化物的异源二聚体。
研究领域：细胞信号传导
研究领域：细胞信号传导
Other Notes
Costrici, N., et al. 1995.Endocrinology136, 4705.
Preparation Note
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多6个月。
由已经认证检测显示对HBsAg以及HIV和HCV抗体呈阴性的个体组织而制备。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
T R Kumar et al.
Nature genetics, 15(2), 201-204 (1997-02-01)
Follicle stimulating hormone (FSH) is a member of the glycoprotein hormone family that includes luteinzing hormone (LH), thyroid stimulating hormone, and chorionic gonadotropin. These heterodimeric hormones share a common alpha subunit and differ in their hormone-specific beta subunit. The biological
Qing R Fan et al.
Nature, 433(7023), 269-277 (2005-01-22)
Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-protein-coupled receptor on the surface of target cells to stimulate testicular and ovarian functions. We present here the 2.9-A-resolution structure of a partially deglycosylated complex of human
Alfredo Ulloa-Aguirre et al.
Endocrinology, 159(8), 3020-3035 (2018-07-10)
FSH is synthesized in the pituitary by gonadotrope cells. By binding to and interacting with its cognate receptor [FSH receptor (FSHR)] in the gonads, this gonadotropin plays a key role in the control of gonadal function and reproduction. Upon activation
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