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F8055

FGR, active, GST tagged human

Name: FGR, active, GST tagged human
Brand: SIGMA

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

SRC2, c-fgr, p55c-fgr

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关于此项目

NACRES:

NA.32

UNSPSC Code:

51111800

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属性

recombinant

expressed in baculovirus infected Sf9 cells

Quality Segment

200

product line

PRECISIO^® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

242-328 nmol/min·mg

mol wt

~86 kDa

UniProt accession no.

P09769

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FGR(2268)

说明

General description

Src family of tyrosine kinases is grouped into two classes- those with wide range of expression, and those with narrow range of tissue expression. Fgr belongs to the latter group. This protein has six functional domains namely, Src homology domain 4 (SH4), a unique domain, SH3 domain, SH2 domain, the catalytic SH1 domain, and a regulatory region in C-terminal. It is expressed in natural killer cells, monocytes and granulocytes.

Biochem/physiol Actions

FGR interacts with Fc?RII and thus, regulates Fc?RII-mediated signaling cascade.
This protein is expressed in B-cells of patients with Epstein-Barr virus-associated lymphoproliferative disease and chronic lymphocytic leukemia. It is also expressed in normal mantle zone B-cells and is controlled developmentally during the differentiation of myelomonocytes.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c