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About This Item
经验公式（希尔记法）:
C9H12FN2O8P
CAS号:
分子量:
326.17
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
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一般描述
5- 5-氟-2′-脱氧尿苷（FdUMP）是胞内生成的5-氟尿嘧啶(5-FU)的代谢产物，5-氟尿嘧啶是一种在分子生物学中应用广泛的试剂，用于研究DNA合成和代谢。
应用
它已被用于：
- 作为抗有丝分裂剂用于培养小鼠原代皮层神经元（primary cortical neuron）。
- 作为培养基成分用于培养小鼠原代皮层神经元。
- 用于胸苷酸合成酶(TS)活性和功能的研究。
生化/生理作用
5-氟-2′-脱氧尿苷-5′-单磷酸盐（FdUMP）是一种 DNA 合成抑制剂。FdUMP 与 RNA 合成抑制剂 3′-C-ethinylcytidine 一起在纳摩尔浓度下诱导宫颈癌细胞死亡。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
W H Gmeiner
Current medicinal chemistry, 12(2), 191-202 (2005-01-11)
Thymidylate synthase (TS) is a well-validated target for cancer chemotherapy. TS was established as the principal target of the widely used anticancer drug 5-fluorouracil (5FU). The 5FU metabolite FdUMP forms a covalent complex with TS that is stabilized by 5-formyl
Induction of apoptosis in cervical cancer cells by the duplex drug 5-FdU--ECyd, coupling 2?-deoxy-5-fluorouridine and 3?-C-ethinylcytidine
Schott S and Bruning A
Gynecologic Oncology, 135(2), 342-348 (2014)
Yoshihiro Nabeya et al.
Cancer science, 102(8), 1509-1515 (2011-05-13)
Thymidylate synthase (TS) plays a major role in the response to 5-fluorouracil (5-FU) by binding directly to the 5-FU metabolite, 5-fluoro-dUMP (FdUMP). The change in the TS expression levels after 5-FU administration was examined in parallel to 5-FU responsiveness in
Manee Chanama et al.
Molecular biology reports, 38(2), 1029-1037 (2010-06-26)
Thymidylate synthase (TS) of Plasmodium dihydrofolate reductase-thymidylate synthase (DHFR-TS) functions as a homodimeric enzyme with two active sites located near the subunit interface. The dimerization is essential for catalysis, since the active site of each subunit contains amino acid residues
G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects
Wang F, et al.
Nucleic Acids Research, 50(22), 12657-12673 (2022)
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