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Merck
CN

F3008

Sigma-Aldrich

抗小鼠IgG(全分子)–FITC 绵羊抗

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.46

生物来源

sheep

质量水平

偶联物

FITC conjugate

抗体形式

affinity isolated antibody

抗体产品类型

secondary antibodies

克隆

polyclonal

形式

buffered aqueous solution

技术

direct immunofluorescence: 1:32

储存温度

2-8°C

靶向翻译后修饰

unmodified

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一般描述

Immunoglobulin G (IgG) is available in large quantities in the human serum. It constitutes about 10-20% of the plasma proteins. IgG is a glycoprotein, with 82-96% proteins and 4-18% carbohydrates. It consists of four sub-classes i.e IgG1, IgG2, IgG3, and IgG4. IgG is composed of four polypeptide chains-two heavy chains (γ chains) and two light chains (κ or λ chains) which are linked by inter-chain disulfide bonds.

应用

Anti-Mouse IgG (whole molecule)−FITC antibody produced in sheep has been used in:
  • flow cytometry
  • immunocytochemistry
  • immunofluorescent staining

生化/生理作用

IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections. The coupling of FITC to Anti- Mouse IgG (whole molecule) antibody allows for the visualization of protein by fluorescent microscopy.

其他说明

Antibody adsorbed with human serum proteins.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

含少量动物源组分生物产品
常规特殊物品

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Masaki Sato et al.
Cancer research, 80(6), 1279-1292 (2020-01-11)
Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the poorest prognoses due to its highly malignant features. BTB and CNC homology 1 (BACH1) has been implicated in RAS-driven tumor formation. We focused on the role of BACH1 in PDAC
Alan Renton et al.
Carcinogenesis, 24(7), 1177-1182 (2003-06-17)
The p53 tumour suppressor gene is a transcription factor that can induce cell cycle arrest and apoptosis. In response to various stress-inducing signals, p53 level increases and this is accompanied with increased activities of p53. Interestingly, the methylxanthine caffeine can
Liang Liu et al.
Antioxidants (Basel, Switzerland), 11(8) (2022-08-27)
BTB and CNC homology 1 (BACH1) represses the expression of genes involved in the metabolism of iron, heme and reactive oxygen species and promotes metastasis of various cancers including pancreatic ductal adenocarcinoma (PDAC). However, it is not clear how BACH1
M A Zimmermann et al.
Haemophilia : the official journal of the World Federation of Hemophilia, 20(3), e215-e221 (2014-03-08)
About 10% of mutations in haemophilia A cases generate a premature termination codon in the factor VIII gene (F8). Upon therapeutic FVIII substitution, it was noted that the risk of developing inhibitors is higher when the nonsense mutation is located
Katsushi Suzuki et al.
PloS one, 15(8), e0236781-e0236781 (2020-08-11)
It has been reported that Bach1-deficient mice show reduced tissue injuries in diverse disease models due to increased expression of heme oxygenase-1 (HO-1)that possesses an antioxidant function. In contrast, we found that Bach1 deficiency in mice exacerbated skeletal muscle injury

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