F0504
Folate binding protein from bovine milk
lyophilized powder
别名:
Folate Protein
biological source
bovine milk
form
lyophilized powder
composition
Protein, 20-40% modified Warburg-Christian
technique(s)
ligand binding assay: suitable, surface plasmon resonance (SPR): suitable
capacity
1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)
storage temp.
−20°C
Quality Level
usage
mg sufficient for ~4,000 assays
Application
Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.
Biochem/physiol Actions
Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.
Packaging
Package size based on protein content
Physical form
Lyophilized powder containing buffer salt as sodium citrate
Analysis Note
Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
低风险生物材料
此项目有
A radioassay for serum folate: use of a two-phase sequential-incubation, ligand-binding system.
S P Rothenberg et al.
The New England journal of medicine, 286(25), 1335-1339 (1972-06-22)
Tumor imaging using P866, a high-relaxivity gadolinium chelate designed for folate receptor targeting
Corot C, et al.
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 60(6), 1337-1346 (2008)
Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein
Jones ML and Nixon PF
The Journal of Nutrition, 132(9), 2690-2694 (2002)
The binding of folic acid and 5-methyltetrahydrofolate to folate-binding proteins during gastric passage differs in a dynamic in vitro gastrointestinal model
Verwei M, et al.
The Journal of Nutrition, 134(1), 31-37 (2004)
Nikki Parker et al.
Analytical biochemistry, 338(2), 284-293 (2005-03-05)
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety of cancers. The current development of folate-targeted cancer therapies has created the need for quantitating functional FRs in clinical specimens. In this article, we
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