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Merck
CN

F0504

Folate binding protein from bovine milk

lyophilized powder

别名:

Folate Protein

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关于此项目

UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00131098

主要文件

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产品名称

Folate binding protein from bovine milk, lyophilized powder

biological source

bovine milk

form

lyophilized powder

composition

Protein, 20-40% modified Warburg-Christian

technique(s)

ligand binding assay: suitable
surface plasmon resonance (SPR): suitable

capacity

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

storage temp.

−20°C

Quality Level

200

usage

 mg sufficient for ~4,000 assays

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Analysis Note

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

Application

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.

Biochem/physiol Actions

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing buffer salt as sodium citrate

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品
低风险生物材料
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000387622
0000316185
0000316185
0000387622
051M7670V

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LRP2 mediates folate uptake in the developing neural tube
Kur E, et al.
Journal of Cell Science, jcs-140145 (2014)
Radioassay of serum folate.
R T Dunn et al.
Clinical chemistry, 19(10), 1101-1105 (1973-10-01)
Martin D Forster et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 71(11), 945-950 (2007-08-23)
The alpha-folate receptor (alpha-FR) is a folate transporter with restricted expression levels in normal tissues. It is over-expressed in several cancers, particularly epithelial carcinomas, including nonmucinous ovarian carcinoma. It offers a novel therapeutic target for selective imaging and cytotoxic agents.
J F Ross et al.
Cancer, 73(9), 2432-2443 (1994-05-01)
Despite significant differences in ligand binding between the two known isoforms of the human membrane folate receptor (FR), designated herein as FR-beta (placenta) and FR-alpha (placenta, KB cells), little is known about their tissue specificities, and there is no report
Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats
Jones ML, et al.
The Journal of Nutrition, 133(2), 489-495 (2003)
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