F0504
Folate binding protein from bovine milk
lyophilized powder
别名:
Folate Protein
biological source
bovine milk
form
lyophilized powder
composition
Protein, 20-40% modified Warburg-Christian
technique(s)
ligand binding assay: suitable, surface plasmon resonance (SPR): suitable
capacity
1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)
storage temp.
−20°C
Quality Level
usage
mg sufficient for ~4,000 assays
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Application
Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.
Biochem/physiol Actions
Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.
Packaging
Package size based on protein content
Physical form
Lyophilized powder containing buffer salt as sodium citrate
Analysis Note
Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
低风险生物材料
此项目有
Radioisotopic assay for measurement of serum folate levels.
S Waxman et al.
Blood, 38(2), 219-228 (1971-08-01)
Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats
Jones ML, et al.
The Journal of Nutrition, 133(2), 489-495 (2003)
LRP2 mediates folate uptake in the developing neural tube
Kur E, et al.
Journal of Cell Science, jcs-140145 (2014)
Radioassay of serum folate.
R T Dunn et al.
Clinical chemistry, 19(10), 1101-1105 (1973-10-01)
Martin D Forster et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 71(11), 945-950 (2007-08-23)
The alpha-folate receptor (alpha-FR) is a folate transporter with restricted expression levels in normal tissues. It is over-expressed in several cancers, particularly epithelial carcinomas, including nonmucinous ovarian carcinoma. It offers a novel therapeutic target for selective imaging and cytotoxic agents.
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