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应用
Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.
生化/生理作用
Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.
包装
Package size based on protein content
质量
Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.
外形
Lyophilized powder containing buffer salt as sodium citrate
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Radioisotopic assay for measurement of serum folate levels.
S Waxman et al.
Blood, 38(2), 219-228 (1971-08-01)
Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats
Jones ML, et al.
The Journal of Nutrition, 133(2), 489-495 (2003)
LRP2 mediates folate uptake in the developing neural tube
Kur E, et al.
Journal of Cell Science, jcs-140145 (2014)
Martin D Forster et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 71(11), 945-950 (2007-08-23)
The alpha-folate receptor (alpha-FR) is a folate transporter with restricted expression levels in normal tissues. It is over-expressed in several cancers, particularly epithelial carcinomas, including nonmucinous ovarian carcinoma. It offers a novel therapeutic target for selective imaging and cytotoxic agents.
Radioassay of serum folate.
R T Dunn et al.
Clinical chemistry, 19(10), 1101-1105 (1973-10-01)
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