检测方案
≥99%
溶解性
DMSO: 38 mg/mL
储存温度
−20°C
SMILES字符串
Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2
InChI
1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
InChI key
INVTYAOGFAGBOE-UHFFFAOYSA-N
基因信息
human ... HDAC1(3065) , HDAC10(83933) , HDAC11(79885) , HDAC2(3066) , HDAC3(8841) , HDAC4(9759) , HDAC5(10014) , HDAC6(10013) , HDAC7(51564) , HDAC8(55869) , HDAC9(9734)
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一般描述
优先于HDAC3（IC50=8 μM）抑制HDAC1（IC50 = 300nM）。 对HDAC8（IC50>100 μM）无抑制活性。
应用
MS-275已被用作组蛋白脱乙酰酶-1抑制剂。
生化/生理作用
HDAC抑制剂，抗增殖。
相关产品
产品编号
说明
价格
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Repr. 1A
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
TingDong Y et al.
Nature Communications, 100 (2018)
Marta Bombardo et al.
Scientific reports, 8(1), 9391-9391 (2018-06-22)
Adult pancreatic acinar cells have the ability to re-enter the cell cycle and proliferate upon injury or tissue loss. Despite this mitotic ability, the extent of acinar proliferation is often limited and unable to completely regenerate the injured tissue or
Heather MacTavish et al.
PloS one, 5(12), e14462-e14462 (2011-02-02)
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV. As attenuated tumour-selective oncolytic vaccinia viruses (VV) are already undergoing clinical evaluation, the
Xuelian Xu et al.
PloS one, 6(2), e17138-e17138 (2011-03-02)
Pediatric acute myeloid leukemia (AML) remains a challenging disease to treat even with intensified cytarabine-based chemotherapy. Histone deacetylases (HDACs) have been reported to be promising therapeutic targets for treating AML. However, HDAC family members that are involved in chemotherapy sensitivities
Ilaria Lepore et al.
PloS one, 8(12), e83018-e83018 (2013-12-19)
Over the past years BARD1 (BRCA1-associated RING domain 1) has been considered as both a BRCA1 (BReast Cancer susceptibility gene 1, early onset) interactor and tumor suppressor gene mutated in breast and ovarian cancers. Despite its role as a stable
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