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Merck
CN

E5156

盐酸依匹斯汀 盐酸盐

≥98% (HPLC), H1 histamine receptor antagonist, solid

别名:

9,13b-Dihydro-1H-dibenz[cf]imidazo[1,5-a]azepine hydrochloride, WAL-801Cl

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关于此项目

经验公式（希尔记法）:
C16H15N3 · HCl
化学文摘社编号:
108929-04-0
分子量:
285.77
UNSPSC Code:
12352200
PubChem Substance ID:
24894608
NACRES:
NA.77
MDL number:
MFCD00933434

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产品名称

盐酸依匹斯汀 盐酸盐, ≥98% (HPLC), solid

SMILES string

Cl[H].NC1=NCC2N1c3ccccc3Cc4ccccc24

InChI key

VKXSGUIOOQPGAF-UHFFFAOYSA-N

InChI

1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: 38 mg/mL

originator

Boehringer Ingelheim

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... HRH1(3269)

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相关类别

General description

Epinastine has antihistamine functions. In mast cells, it may modulate cytokine and chemokine production. In dendritic cells, it controls T helper cell mediated immune response. Epinastine hydrochloride does not traverse the brain barrier. Oral dosage of epinastine hydrochloride is prescribed for children with sleep-disordered breathing (SDB) and nasal inflammation. Ophthalmic solution of epinastine is effective for allergic conjunctivitis.

Biochem/physiol Actions

Epinastine hydrochloride is a non-sedating H1 histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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分析证书(COA)

Lot/Batch Number
0000475790
0000475791
0000475791
0000475790
0000377982

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Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro
Asano K, et al.
Mediators of Inflammation, 2008 (2008)
The Effectiveness of Epinastine Hydrochloride for Pediatric Sleep-Disordered Breathing Related Symptoms Caused By Hyperesthetic Non-Infectious Rhinitis
Hara H, et al.
Otolaryngology, 4(150), 2-2 (2013)
Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children
Sarashina A, et al.
British Journal of Clinical Pharmacology, 59(1), 43-53 (2005)
Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cells in vitro and in vivo
Oshima KZ, et al.
Mediators of Inflammation, 2009 (2009)
Masanori Ito et al.
International journal of pharmaceutics, 441(1-2), 121-127 (2012-12-19)
The study objective was to quantitatively predict a drug's bitterness and estimate bitterness masking efficiency using an electronic tongue (e-Tongue). To verify the predicted bitterness by e-Tongue, actual bitterness scores were determined by human sensory testing. In the first study
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