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E2387

Sigma-Aldrich

NECA

≥98% (TLC), powder, adenosine receptor agonist

别名:

乙基咔唑

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About This Item

经验公式（希尔记法）:
C12H16N6O4
CAS号:
35920-39-9
分子量:
308.29
MDL编号:
MFCD00069195
UNSPSC代码:
12352200
PubChem化学物质编号:
24277684
NACRES:
NA.77

产品名称

5'-（N-乙基羧酰胺基）腺苷, powder

表单

powder

质量水平

200

颜色

white

溶解性

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL (Solutions may be stored for several days at 4 °C.)
DMSO: 14 mg/mL (Solutions may be stored for several days at 4 °C.)
0.1 M HCl: 3.4 mg/mL (Solutions may be stored for several days at 4 °C.)
H2O: insoluble
ethanol: soluble (Solutions may be stored for several days at 4 °C.)

储存温度

2-8°C

SMILES字符串

CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1

InChI key

JADDQZYHOWSFJD-FLNNQWSLSA-N

基因信息

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)
rat ... Adora1(29290) , Adora2a(25369) , Adora2b(29316) , Adora3(25370)

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一般描述

5′-(N-乙基酰胺基）腺苷通过 A2-腺苷受体激活刺激肺循环中的血管舒张。

应用

5′-(N-乙基酰胺基）腺苷用于：
  • 纯化癸基麦芽糖苷（DM）中的人腺苷A2A受体（A2AR）
  • 确定腺苷受体非特异性结合情况
  • 通过竞争性测定研究腺苷2B受体（RA2B）的作用机理

生化/生理作用

强效腺苷受体激动剂与 A 1 和 A 2 受体的亲和力几乎相等。

特点和优势

《受体分类和信号转导》手册的 腺苷受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

预防措施声明

P264 - P301 + P310

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000340719
0000340719
0000219058
0000216316
0000216316

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