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Merck
CN

D9500

Sigma-Aldrich

2′-脱氧鸟苷5′-单磷酸 钠盐 水合物

≥99% (HPLC)

别名:

5′-脱氧鸟苷酸, dGMP

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About This Item

经验公式(希尔记法):
C10H14N5O7P · xNa+ · yH2O
分子量:
347.22 (anhydrous free acid basis)
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51

质量水平

方案

≥99% (HPLC)

表单

powder

溶解性

water: 50 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

O.[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP(O)([O-])=O)O3)C(=O)N1

InChI

1S/C10H14N5O7P.Na.H2O/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20;;/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17);;1H2/q;+1;/p-1/t4-,5+,6+;;/m0../s1

InChI key

UVKXYXSKMTUDML-FVALZTRZSA-M

应用

2′-脱氧鸟苷5′-单磷酸酯(dGMP)用作鸟苷酸激酶(EC 2.7.4.8)的底物,形成dGDP,磷酸化为dGTP后可支持DNA生物合成。dGMP用于研究鸟嘌呤类分子的理化特性。
2′-脱氧鸟苷5′-单磷酸钠盐水合物已被用于:
  • 反相高压力液相色谱(HPLC)分析
  • 确定脱氧单核苷酸对自发增殖的CaCo-2细胞系的影响
  • 确定其刺激免疫细胞生长和功能的能力,并在体外使用流行性感冒病毒抗原作为免疫刺激剂

储存分类代码

11 - Combustible Solids

WGK

WGK 3


历史批次信息供参考:

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Brian G Gentry et al.
Biochemical pharmacology, 81(1), 43-49 (2010-09-18)
Many fraudulent nucleosides including the antivirals acyclovir (ACV) and ganciclovir (GCV) must be metabolized to triphosphates to be active. Cyclopropavir (CPV) is a newer, related guanosine nucleoside analog that is active against human cytomegalovirus (HCMV) in vitro and in vivo.
Mahmoud Kandeel et al.
Molecular and biochemical parasitology, 159(2), 130-133 (2008-04-01)
The present work describes cloning, expression, purification, characterization, and mutation of Plasmodium falciparum guanylate kinase (PlasmoDB ID PFI1420w). Amino-acid sequence alignment revealed important differences especially in K42-V51, Y73-A77, and F100-L110, which include residues important for kinase activity, and at helix
Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion
Holen E, et al.
Nutrition, 22(1), 90-96 (2006)
Dietary nucleotides and intestinal cell lines: I. Modulation of growth
Holen E and Jonsson R
Nutrition Research (New York, N.Y.), 24(3), 197-207 (2004)
Ana-Maria Ruxandra Eftimie et al.
Roumanian archives of microbiology and immunology, 66(1-2), 22-25 (2008-10-22)
Guanylate kinase is a member of the nucleoside monophosphate (NMP) kinase family, a family of enzymes that despite having a low primary structure identity share a similar fold, which consists of three structurally distinct regions termed the CORE, LID, and

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