D9250
2′-脱氧鸟苷5′-二磷酸 钠盐
≥90% (HPLC), powder
别名:
dGDP
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关于此项目
经验公式（希尔记法）:
C10H15N5O10P2 · xNa+
化学文摘社编号:
分子量:
427.20 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
产品名称
2′-脱氧鸟苷5′-二磷酸 钠盐, ≥90% (HPLC)
SMILES string
[Na].NC1=NC(=O)c2ncn(C3CC(O)C(COP(O)(=O)OP(O)(O)=O)O3)c2N1
InChI
1S/C10H15N5O10P2.Na.H/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20;;/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17);;
InChI key
VLWIICGGBFZYEZ-UHFFFAOYSA-N
assay
≥90% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
相关类别
Application
2′-脱氧鸟苷 5′-二磷酸 （dGDP）可用作 dGDP（核苷二磷酸）激酶 （2.7.4.6） 或丙酮酸激酶的底物，以产生 dGTP，支持 DNA 生物合成。 dGDP 可用作研究噬菌体 T7 表达的糖蛋白（gp） 1.7 的动力学的底物。
2′-脱氧鸟苷 5′-二磷酸钠盐已在动力学研究中被用作黄嘌呤 5′-单磷酸类似物和黄嘌呤磷酸核糖基转移酶抑制剂。
Biochem/physiol Actions
2′-脱氧鸟苷 5′-二磷酸 （dGDP）抑制黄嘌呤磷酸核糖基转移酶（XPRT）和次黄嘌呤-鸟嘌呤磷酸核糖基转移酶 (HGPRT)。
General description
2′-脱氧鸟苷 5′-二磷酸 （dGDP）是具有鸟嘌呤碱基、脱氧核糖和两个磷酸盐的核苷酸。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Ngoc Q Tran et al.
Molecular microbiology, 77(2), 492-504 (2010-05-26)
Gene 1.7 of bacteriophage T7 confers sensitivity of both phage T7 and its host Escherichia coli to dideoxythymidine (ddT). We have purified the product of gene 1.7, gp1.7. It exists in two forms of molecular weight 22,181 and 17,782. Only
Jiande Gu et al.
Nucleic acids research, 35(15), 5165-5172 (2007-07-31)
The 2'-deoxyguanosine-3',5'-diphosphate, 2'-deoxyadenosine-3',5'-diphosphate, 2'-deoxycytidine-3',5'-diphosphate and 2'-deoxythymidine-3',5'-diphosphate systems are the smallest units of a DNA single strand. Exploring these comprehensive subunits with reliable density functional methods enables one to approach reasonable predictions of the properties of DNA single strands. With these
Jie Bao et al.
Biotechnology and bioengineering, 89(4), 485-491 (2005-01-12)
The enzyme reaction mechanism and kinetics for biosyntheses of deoxyadenosine triphosphate (dATP) and deoxyguanosine triphosphate (dGTP) from the corresponding deoxyadenosine diphosphate (dADP) and deoxyguanosine diphosphate (dGDP) catalyzed by pyruvate kinase were studied. A kinetic model for this synthetic reaction was
Ngoc Q Tran et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(27), 9373-9378 (2008-07-05)
Bacteriophage T7 DNA polymerase efficiently incorporates dideoxynucleotides into DNA, resulting in chain termination. Dideoxythymidine (ddT) present in the medium at levels not toxic to Escherichia coli inhibits phage T7. We isolated 95 T7 phage mutants that were resistant to ddT.
Bhumi Patel et al.
Biochimica et biophysica acta. Proteins and proteomics, 1866(3), 426-441 (2017-12-14)
Among all PRT enzymes of purine salvage pathway in Leishmania, XPRT (Xanthine phosphoribosyl transferase) is unique in its substrate specificity and their non-existence in human. It is an interesting protein not only for drug designing but also to understand the
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