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Merck
CN

D8893

Sigma-Aldrich

地塞米松

powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

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别名:
(11β,16α)-9-氟-11,17,21-三羟基-16-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16α-甲基-11β,17α,21-三羟基-1,4-妊娠双烯-3,20-二酮, 9α-氟-16α-甲基泼尼松龙, 泼尼松龙F
经验公式(希尔记法):
C22H29FO5
CAS号:
分子量:
392.46
Beilstein:
2066651
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

无菌性

γ-irradiated

产品线

BioXtra

检测方案

≥80% (HPLC)

形式

powder

效能

4-500 ng/mL

技术

cell culture | mammalian: suitable

mp

262-264 °C (lit.)

溶解性

ethanol: 1 mL/vial, clear

运输

ambient

储存温度

2-8°C

SMILES字符串

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

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应用

地塞米松已被用作成骨分化培养基的组成成分。它还用于研究细胞凋亡、细胞信号传导通路和基因表达。

生化/生理作用

地塞米松具有免疫抑制和止吐特性。它用于治疗术后恶心呕吐(PONV)以及化疗引起的恶心呕吐(CINV)。地塞米松在心脏移植、败血症、癌症等病理疾病中发挥着重要作用。它会提升热休克蛋白的水平。它是一种抗炎糖皮质素,对细胞存活、细胞信号传导和基因表达具有一系列的影响。
糖皮质激素抗炎剂。 调节T细胞生存、生长和分化。抑制一氧化氮合酶活性的诱导。

外形

粉末2-8 °C;按照工作液量分装后冻存,避免反复冻融

重悬

要制备20 μg/ml储备液:加入1 ml无水乙醇;轻轻旋转溶解;混合时加入49 ml无菌培养基。

象形图

Health hazard

警示用语:

Danger

危险声明

危险分类

Repr. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the best way to dissolve Product D8893, Dexamethasone?

    The solubility of dexamethasone is <0.01 mg/mL in water and 24 mg/mL in H5784 (a 45% w/v solution of 2-hydroxypropyl-β-cyclodextrin).

  6. What is the solubility of Product D8893, Dexamethasone, in ethanol?

    The product is soluble in 95% ethanol (1mg/mL), yielding a clear, colorless solution. A 20 μg/mL stock solution can be formed by adding 49 mL of media to 1 mL of a 1 mg/mL ethanol stock.

  7. What is the solubility of Product D8893, Dexamethasone, in DMSO?

    The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.

  8. What solution stability information do you have available for Product D8893, Dexamethasone?

    We would recommend that you store stock solutions in working aliquots frozen at -20°C. It is best to avoid repeated freeze/thaw cycles.

  9. How do the dexamethasone products D8893 and the D4902 compare?

    They are the same except for the sterility. D8893 has been g-irradiated, so it is sterile. The D4902 is not necessarily sterile. Both are cell culture tested by Sigma.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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