D8008
7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
≥95%
别名:
DEDA
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关于此项目
经验公式（希尔记法）:
C22H40O2
化学文摘社编号:
分子量:
336.55
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
InChI
1S/C22H40O2/c1-4-5-6-7-8-9-10-11-12-13-16-19-22(2,3)20-17-14-15-18-21(23)24/h16-17,19-20H,4-15,18H2,1-3H3,(H,23,24)/b19-16-,20-17-
SMILES string
CCCCCCCCCCC\C=C/C(C)(C)\C=C/CCCC(O)=O
InChI key
AGKRHAILCPYNFH-DUQSFWPASA-N
biological source
synthetic (organic)
assay
≥95%
form
liquid
storage temp.
−20°C
Gene Information
human ... ADORA2A(135), ADORA2B(136)
Biochem/physiol Actions
Inhibitor of phospholipase A2 and lipoxygenase. Inhibits endogenous synthesis of leukotrienes.
存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
C S Ramesha et al.
Analytical biochemistry, 192(1), 173-180 (1991-01-01)
a simple gas chromatographic method for the assay of phospholipase A2 (PLA2) has been described in which arachidonic acid released from endogenous phospholipid pools is measured following its extraction and derivatization to pentafluorobenzyl esters. Using this assay, PLA2 activities in
D G Johns et al.
The American journal of physiology, 275(5 Pt 2), H1592-H1598 (1998-11-14)
Ceramide is a novel second messenger generated by hydrolysis of membrane sphingomyelin by a neutral sphingomyelinase (nSMase). Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been shown to increase intracellular ceramide through phospholipase A2 (PLA2)-dependent activation of nSMase. TNF-alpha has
R T Worrell et al.
American journal of physiology. Cell physiology, 281(1), C147-C156 (2001-06-13)
Activity of the epithelial Na+ channel (ENaC) is the limiting step for discretionary Na+ reabsorption in the cortical collecting duct. Xenopus laevis kidney A6 cells were used to investigate the effects of cytosolic phospholipase A2 (cPLA2) activity on Na+ transport.
Thomas L Williams et al.
Langmuir : the ACS journal of surfaces and colloids, 22(15), 6473-6476 (2006-07-13)
This letter describes a new method for studying the interaction of the membrane-lysing enzyme phospholipase A(2) (PLA(2)) with phospholipid bilayers by simultaneous measurements of enzyme binding and vesicle lysis using surface plasmon resonance (SPR) and permeabilization using surface plasmon field-enhanced
Yinchun Jiao et al.
Molecules (Basel, Switzerland), 25(18) (2020-09-10)
We show that natural bond orbital (NBO) and natural resonance theory (NRT) analysis methods provide both optimized Lewis-structural bonding descriptors for ground-state electronic properties as well as suitable building blocks for idealized "diabatic" two-state models of the associated spectroscopic excitations.
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