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D7750

2′-脱氧胞苷 5′-单磷酸

Name: 2′-脱氧胞苷 5′-单磷酸
Brand: SIGMA

≥95.0%, synthetic, powder

别名:

dCMP, 胞嘧啶脱氧核苷酸

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关于此项目

经验公式（希尔记法）:

C₉H₁₄N₃O₇P

化学文摘社编号:

1032-65-1

分子量:

307.20

NACRES:

NA.51

PubChem Substance ID:

24894158

UNSPSC Code:

41106305

EC Number:

213-849-9

MDL number:

MFCD00006546

Beilstein/REAXYS Number:

41062

Assay:

≥95.0%

Biological source:

synthetic

Form:

powder

Solubility:

1 M NH₄OH: 50 mg/mL, clear, colorless

Storage temp.:

−20°C

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属性

产品名称

2′-脱氧胞苷 5′-单磷酸, Sigma Grade, ≥95.0%

biological source

synthetic

Quality Level

200

grade

Sigma Grade

assay

≥95.0%

form

powder

solubility

1 M NH₄OH: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2

InChI

1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1

InChI key

NCMVOABPESMRCP-SHYZEUOFSA-N

说明

General description

2′-脱氧胞苷 5′-单磷酸酯是构成DNA的脱氧核苷酸的结构单元。它由通过N-β-D-糖苷键连接含氮杂环胞嘧啶而形成的2′-脱氧-β-D-呋喃核糖组成。它在C-5 处被磷酸化′。

Application

2′-脱氧胞苷5′-单磷酸酯已被用于拉曼光谱研究，以确定其拉曼总半带宽。

2'-脱氧胞苷5'-单磷酸（dCMP）利用尿苷单磷酸（UMP）/单磷酸胞苷（CMP）激酶（EC 2.7.4.4）的底物，形成dCDP，其在磷酸化为dCTP时支持DNA生物合成。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Essentials of Chemical biology (2013)

miR-221 promotes growth and invasion of hepatocellular carcinoma cells by constitutive activation of NFκB.

Zimin Liu et al.

American journal of translational research, 8(11), 4764-4777 (2016-12-03)

microRNAs (miRs) are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. Accumulating evidence suggests that microRNA-221 (miR-221) plays important roles in human carcinogenesis. It

A comparative picosecond transient infrared study of 1-methylcytosine and 5'-dCMP that sheds further light on the excited states of cytosine derivatives.

Páraic M Keane et al.

Journal of the American Chemical Society, 133(12), 4212-4215 (2011-03-10)

The role of N1-substitution in controlling the deactivation processes in photoexcited cytosine derivatives has been explored using picosecond time-resolved IR spectroscopy. The simplest N1-substituted derivative, 1-methylcytosine, exhibits relaxation dynamics similar to the cytosine nucleobase and distinct from the biologically relevant

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全球贸易项目编号

货号	GTIN
D7750-1G	04061826690611