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Merck
CN

D7692

Sigma-Aldrich

磷酸二乙基伞形酮

≥98% (HPLC), oil

别名:

DEUP, UBP

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About This Item

经验公式(希尔记法):
C14H17O6P
CAS号:
分子量:
312.25
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

oil

颜色

colorless to yellow

溶解性

DMSO: >5 mg/mL

储存温度

−20°C

SMILES字符串

CCOP(=O)(OCC)Oc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C14H17O6P/c1-4-17-21(16,18-5-2)20-11-6-7-12-10(3)8-14(15)19-13(12)9-11/h6-9H,4-5H2,1-3H3

InChI key

GHGRYKAFUNNHBG-UHFFFAOYSA-N

相关类别

应用

磷酸二乙酯已被用作脂肪酶抑制剂来治疗野生型成髓细胞,以进行体外中性粒细胞分化试验。

生化/生理作用

二乙基伞形磷酸酯(DEUP)是一种在体外不阻断蛋白激酶活性A的有机磷酸酯。
二乙基伞形酮磷酸酯是一种选择性的、有效的胆固醇酯酶抑制剂。它主要通过防止胆固醇转运到类固醇生成细胞的线粒体中来阻止类固醇生成。预期胆固醇酯酶抑制剂会限制饮食中胆固醇的吸收。IC50 = 11.6 μM。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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分析证书(COA)

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Momoko Yamagata et al.
Experimental brain research, 236(5), 1501-1517 (2018-03-23)
We explored the relations between indices of mechanical stability of vertical posture and synergy indices under unexpected perturbations. The main hypotheses predicted higher posture-stabilizing synergy indices and higher mechanical indices of center of pressure stability during perturbations perceived by subjects
Rickson C Mesquita et al.
Biomedical optics express, 1(1), 324-336 (2011-01-25)
Resting state connectivity aims to identify spontaneous cerebral hemodynamic fluctuations that reflect neuronal activity at rest. In this study, we investigated the spatial-temporal correlation of hemoglobin concentration signals over the whole head during the resting state. By choosing a source-detector
Brent D Fulton et al.
The American journal of managed care, 23(10), 596-603 (2017-11-01)
In 2011, the California Right Care Initiative implemented a countywide physician organization learning collaborative called University of Best Practices (UBP) in San Diego County for major healthcare systems and physician organizations to share best practices in managing cardiovascular and cerebrovascular
Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation
Riffelmacher T, et al.
Immunity, 47(3), 466-480 (2017)
Y S Choi et al.
European journal of biochemistry, 234(2), 680-685 (1995-12-01)
Diethylumbelliferyl phosphate (DEUP) is an organophosphate cholesteryl ester hydrolase inhibitor that blocks steroidogenesis mainly by preventing cholesterol transport into the mitochondria of steroidogenic cells. In the present study, we show that DEUP blocks the cAMP-stimulated mitochondrial accumulation of the 30-kDa

商品

胆固醇酯化可改善运输。胆固醇酯可更轻松地封装在脂蛋白内部-增加了在血液中可轻松运输的胆固醇数量。

Cholesterol esterification enhances transport efficiency in lipoproteins for increased blood stream transport.

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