推荐产品
生物来源
synthetic
质量水平
检测方案
≥98% (TLC)
形式
powder
mp
283-285 °C
溶解性
methanol: 50 mg/mL, clear, colorless to faint yellow or tan
创始人
Novartis
储存温度
room temp
SMILES字符串
[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI
1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
InChI key
KPHWPUGNDIVLNH-UHFFFAOYSA-M
基因信息
human ... PTGS1(5742) , PTGS2(5743)
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应用
双氯芬酸钠已被用于:
- 辐射防护潜力研究
- 确定增溶剂及其胶束加合物的基本粘度和流体动力学值
- 作为顺序注射分析系统中双氯芬酸的电位滴定和荧光测定的标准品
- 抑制II期药物代谢酶(DME),以研究播娘蒿种子的乙醇提取物对I期和II期DME的抑制作用
生化/生理作用
双氯芬酸钠盐是一种非甾体类抗炎药(NSAID),可作为前列腺素合成酶的竞争性和不可逆的抑制剂。其镇痛和抗炎活性基于环加氧酶的抑制活性来预防花生四烯酸代谢物的合成。研究发现它可阻碍花生四烯酸转化为前列腺素,其中前列腺素可介导炎症过程。NSAID被发现可抑制环氧合酶COX-1和COX-2,从而引起非期望的胃肠道作用。双氯芬酸钠还起到清除自由基的作用,并且在恢复由辐射损坏的质粒DNA的超螺旋结构方面起到辐射保护作用。双氯芬酸钠通过电子的给予和氢原子的转移而被氧化。它可以作为潜在的辐射防护剂。
标准NSAID和环加氧酶(COX)抑制剂。主要代谢物是4′-羟基二苯甲酸和5′-羟基二氯芬酸。已被用作CYP2C9的选择性底物。
特点和优势
该化合物是ADME Tox研究的推荐产品。点击此处,了解更多精选ADME Tox产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问 sigma.com/discover-bsm。
警示用语:
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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