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安全信息

D6134

Sigma-Aldrich

D-2-脱氧葡萄糖

≥99% (GC), crystalline

别名:

2-脱氧-D-葡糖

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About This Item

经验公式（希尔记法）:
C6H12O5
CAS号:
154-17-6
分子量:
164.16
Beilstein:
1723331
EC 号:
205-823-0
MDL编号:
MFCD00151328
UNSPSC代码:
12352201
PubChem化学物质编号:
24894000
NACRES:
NA.25
产品D6134监管中，请联系销售询价或购买 联系客户支持

生物来源

synthetic (organic)

质量水平

200

方案

≥99% (GC)

表单

crystalline

技术

gas chromatography (GC): suitable

颜色

white

mp

146-147 °C (lit.)

溶解性

H2O: soluble 330 mg/mL, clear, colorless

储存温度

2-8°C

SMILES字符串

OC[C@@H](O)[C@@H](O)[C@H](O)CC=O

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此商品
D8375D3179M9376
D-2-脱氧葡萄糖 ≥99% (GC), crystalline

D6134

D-2-脱氧葡萄糖

D-2-脱氧葡萄糖 ≥98% (GC), crystalline

D8375

D-2-脱氧葡萄糖

D-2-脱氧葡萄糖 ≥98% (GC), BioXtra

D3179

D-2-脱氧葡萄糖

甲基α-D-吡喃葡萄糖苷 ≥99% (GC)

M9376

甲基α-D-吡喃葡萄糖苷

biological source

synthetic (organic)

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, inhibition assay: suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

assay

≥99% (GC)

assay

≥98% (GC)

assay

≥98% (GC)

assay

≥99% (GC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

H2O: soluble 330 mg/mL, clear, colorless

solubility

H2O: 0.250 g/5mL

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

water: 50 mg/mL, clear, colorless

form

crystalline

form

crystalline

form

powder

form

powder

应用

2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.

生化/生理作用

2-脱氧-D-葡萄糖（2-脱氧葡萄糖）是一种葡萄糖类似物，可通过作用于己糖激酶这一糖酵解限速步骤来抑制糖酵解。 它会被己糖激酶磷酸化为不能被磷酸葡萄糖异构酶进一步代谢的2-DG-P。 这将导致2-DG-P在细胞中的集聚以及细胞ATP的缺失。在体外，2-脱氧葡萄糖已显示出可诱导自噬、提高ROS的产生并激活AMPK。

制备说明

A further purification of the Grade II material by recrystallization.

其他说明

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000445018
    0000445018
    0000444333
    0000444333
    0000435716

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    如果您需要特殊版本，可通过批号或批次号查找具体证书。

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    在文件库中查找您最近购买产品的文档。

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    1. Which document(s) contains shelf-life or expiration date information for a given product?

      If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

    2. How do I get lot-specific information or a Certificate of Analysis?

      The lot specific COA document can be found by entering the lot number above under the "Documents" section.

    3. How can I dissolve 2-Deoxy-D-glucose, Product D6134?

      The product is soluble in water at 330 mg/mL.  It may also be soluble in DMSO.

    4. Can solutions of 2-Deoxy-D-glucose, Product D6134, be stored?

      Sigma-Aldrich has no information on the solution stability of this product.  If information can't be found in the literature, it is best to prepare fresh solutions.

    5. What is the shelf life of 2-Deoxy-D-glucose, Product D6134?

      There is no recommended retest date given to released lots for this product. The product is guaranteed to be of good quality for one year from the time you receive it; this guarantee applies only to unopened bottles which have been stored at room temperature.

    6. What are the differences between products D6134 and D8375 which are both 2-deoxy-D-glucose?

      Product D6134 is a further purification by crystallization of D8375.

    7. How do I find price and availability?

      There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

    8. What is the Department of Transportation shipping information for this product?

      Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

    9. My question is not addressed here, how can I contact Technical Service for assistance?

      Ask a Scientist here.

    Alfredo J Ibáñez et al.
    Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8790-8794 (2013-05-15)
    Single-cell level measurements are necessary to characterize the intrinsic biological variability in a population of cells. In this study, we demonstrate that, with the microarrays for mass spectrometry platform, we are able to observe this variability. We monitor environmentally (2-deoxy-D-glucose)
    Rosemarie Ungricht et al.
    The Journal of cell biology, 209(5), 687-703 (2015-06-10)
    Newly synthesized membrane proteins are constantly sorted from the endoplasmic reticulum (ER) to various membranous compartments. How proteins specifically enrich at the inner nuclear membrane (INM) is not well understood. We have established a visual in vitro assay to measure
    Melissa A Burmeister et al.
    American journal of physiology. Endocrinology and metabolism, 304(7), E677-E685 (2013-01-24)
    Glucagon-like peptide-1 (GLP-1) suppresses food intake via activation of a central (i.e., brain) GLP-1 receptor (GLP-1R). Central AMP-activated protein kinase (AMPK) is a nutrient-sensitive regulator of food intake that is inhibited by anorectic signals. The anorectic effect elicited by hindbrain
    Isaline Rowe et al.
    Nature medicine, 19(4), 488-493 (2013-03-26)
    Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by bilateral renal cyst formation. Recent identification of signaling cascades deregulated in ADPKD has led to the initiation of several clinical trials, but an approved therapy is still
    Paramita Chakraborty et al.
    Cell reports, 28(7), 1879-1893 (2019-08-15)
    Sphingosine 1-phosphate (S1P), a bioactive lysophospholipid generated by sphingosine kinase 1 (SphK1), regulates lymphocyte egress into circulation via S1P receptor 1 (S1PR1) signaling, and it controls the differentiation of regulatory T cells (Tregs) and T helper-17 cells. However, the mechanisms by
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