所有图片(4)
About This Item
线性分子式:
C9H11N2O8PNa2
CAS号:
分子量:
352.15
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
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一般描述
2′-脱氧尿苷5′-单磷酸二钠盐（dUMP）是胸苷酸合酶的底物，并转化为脱氧胸苷单磷酸（dTMP）。
应用
2′-脱氧尿苷-5′-单磷酸二钠盐已用于：
- 超高效液相色谱-串联质谱（UPLC/MS/MS）法测定
- 刺激暴露于流行性感冒病毒抗原人外周血单个核细胞（PBMC）的增殖
- 胸苷酸合成酶活性测定幽门螺杆菌
苷酸合成酶（TS）（EC 2.1.1.45）使用2′-脱氧尿苷5′-单磷酸（dUMP）从头生产dTMP。在潜在的化疗应用中研究dUMP类似物时，将dUMP用作参考底物。
生化/生理作用
甲氨蝶呤可抑制2′-脱氧尿苷5′-单磷酸二钠盐（dUMP）转化为嘧啶。在甲基化步骤中将dUMP抑制为脱氧胸苷单磷酸（dTMP）是控制细菌和真核细胞生长的关键。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Adam Jarmuła et al.
Bioorganic & medicinal chemistry, 15(6), 2346-2358 (2007-02-06)
Thymidylate synthase (TS) is a target enzyme for a number of anticancer agents including the 5-fluorouracil metabolite, FdUMP. The present paper reports on molecular modeling studies of the effect of substitution at C(5) position in the pyrimidine ring of the
Eric M Koehn et al.
Nature, 458(7240), 919-923 (2009-04-17)
Biosynthesis of the DNA base thymine depends on activity of the enzyme thymidylate synthase to catalyse the methylation of the uracil moiety of 2'-deoxyuridine-5'-monophosphate. All known thymidylate synthases rely on an active site residue of the enzyme to activate 2'-deoxyuridine-5'-monophosphate.
Biochemistry: Anchors away.
Maria Paola Costi et al.
Nature, 458(7240), 840-841 (2009-04-17)
Glyn R Hemsworth et al.
The Journal of biological chemistry, 286(18), 16470-16481 (2011-04-02)
Members of the Leishmania genus are the causative agents of the life-threatening disease leishmaniasis. New drugs are being sought due to increasing resistance and adverse side effects with current treatments. The knowledge that dUTPase is an essential enzyme and that
Peter S Ludwig et al.
European journal of medicinal chemistry, 40(5), 494-504 (2005-05-17)
Amphiphilic anticancer prodrugs of 5'-fluoro-2'-deoxyuridine-5'-monophosphate (5-FdUMP) were synthesized according to the hydrogen phosphonate method by coupling lipophilic cytosine derivatives or a phospholipid with 5-fluoro-2'-deoxyuridine (5-FdU). Studies within the in vitro Anticancer Screen Program of the National Cancer Institute have demonstrated
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