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D2813

4,5-二氨基荧光素二乙酸酯

Name: 4,5-二氨基荧光素二乙酸酯
Brand: SIGMA

≥98% purity (HPLC), lyophilized powder

别名:

DAF-2 DA

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About This Item

经验公式（希尔记法）:

C₂₄H₁₈N₂O₇

CAS号:

205391-02-2

分子量:

446.41

MDL编号:

MFCD05865101

UNSPSC代码:

12171500

PubChem化学物质编号:

329798754

NACRES:

NA.47

product name

4,5-二氨基荧光素二乙酸酯, ≥98% (HPLC)

质量水平

100

检测方案

≥98% (HPLC)

形式

lyophilized powder

颜色

colorless to white

溶解性

DMSO: <2 mg/mL
H₂O: <2 mg/mL

应用

diagnostic assay manufacturing
hematology
histology

运输

wet ice

储存温度

2-8°C

SMILES字符串

O=C1OC2(C3=C(OC4=C2C=CC(OC(C)=O)=C4)C=C(OC(C)=O)C=C3)C5=C1C=C(N)C(N)=C5

InChI

1S/C24H18N2O7/c1-11(27)30-13-3-5-16-21(7-13)32-22-8-14(31-12(2)28)4-6-17(22)24(16)18-10-20(26)19(25)9-15(18)23(29)33-24/h3-10H,25-26H2,1-2H3

InChI key

PTSUYDXEEKDBQU-UHFFFAOYSA-N

应用

4,5-二氨基荧光素二乙酸酯 (DAF-2 Da) 已被用作 NO（一氧化氮）检测的荧光染料。

活细胞中一氧化氮的细胞渗透荧光检测器。

法律信息

DAF-2 由 Daiichi Pure Chemicals Co.,LTD. 生产。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Graphene Oxides Show Angiogenic Properties.

Mukherjee S, et al.

Advanced Helathcare Materials, 4, 1722-1732 (2015)

Vitamin C prevents the endothelial dysfunction induced by acute ethanol intake.

Hipolito UV, et al.

Life Sciences, 141, 99-107 (2015)

Phospholipase dalpha1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis.

Yanyan Zhang et al.

The Plant cell, 21(8), 2357-2377 (2009-08-20)

We determined the role of Phospholipase Dalpha1 (PLDalpha1) and its lipid product phosphatidic acid (PA) in abscisic acid (ABA)-induced production of reactive oxygen species (ROS) in Arabidopsis thaliana guard cells. The pldalpha1 mutant failed to produce ROS in guard cells

NADPH oxidase-2 inhibition restores contractility and intracellular calcium handling and reduces arrhythmogenicity in dystrophic cardiomyopathy.

Daniel R Gonzalez et al.

American journal of physiology. Heart and circulatory physiology, 307(5), H710-H721 (2014-07-13)

Duchenne muscular dystrophy may affect cardiac muscle, producing a dystrophic cardiomyopathy in humans and the mdx mouse. We tested the hypothesis that oxidative stress participates in disrupting calcium handling and contractility in the mdx mouse with established cardiomyopathy. We found

Rho-kinase activation contributes to Lps-induced impairment of endothelial nitric oxide synthase activation by endothelin-1 in cultured hepatic sinusoidal endothelial cells.

Willson Kwok et al.

Shock (Augusta, Ga.), 42(6), 554-561 (2014-09-23)

The purpose of this study is to understand the role of rho-kinase (ROCK-2) in the regulation of liver microcirculation after inflammatory stress. Endothelin-1 (ET-1)-induced nitric oxide (NO) is essential in the regulation of blood flow in hepatic sinusoids. Lipopolysaccharide (LPS)

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感应染料

一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

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