D2521
(+)-顺式-地尔硫卓 盐酸盐
≥99% (HPLC), L-type Ca2+ channel blocker, powder
别名:
(2S,3S)-(+)-顺式-3-乙酰氧基-5-(2-二甲基氨基乙基)-2,3-二氢-2-(4-甲氧基苯基)-1,5-苯并硫氮杂-4(5H)- 酮 盐酸盐, CRD-401
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C22H26N2O4S · HCl
化学文摘社编号:
分子量:
450.98
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
251-443-3
MDL number:
Beilstein/REAXYS Number:
4228706
产品名称
(+)-顺式-地尔硫卓 盐酸盐, ≥99% (HPLC)
Quality Level
assay
≥99% (HPLC)
form
powder
originator
Valeant
storage temp.
2-8°C
SMILES string
Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O
InChI
1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
InChI key
HDRXZJPWHTXQRI-BHDTVMLSSA-N
Gene Information
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
General description
盐酸地尔硫卓可用于治疗心血管疾病，例如心绞痛和高血压。它可充当细胞色素P450 3A（CYP3A）的抑制剂。地尔硫卓可能与斑丘疹、荨麻疹和瘙痒有关。
Application
(+)-顺式-盐酸地尔硫卓已用于:
- 研究其对整体分散基质（monolithic dispersion matrix）中扩散和释放的影响（26）
- 研究其在视网膜色素变性（RP）模型中的神经保护作用（27）
- 作为Cav1.2 L型钙通道（LTCC）的拮抗剂（28）
Biochem/physiol Actions
封闭缓慢或L-型Ca2+通道；调节来自中性粒细胞内存储的Ca2+的释放；刺激1,4-二氢吡啶结合至Ca2+通道；冠状动脉舒张剂。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Diltiazem induces severe photodistributed hyperpigmentation: case series, histoimmunopathology, management, and review of the literature
Saladi RN, et al.
Archives of Dermatology, 142(2), 206-210 (2006)
M J Gunthorpe et al.
The Journal of physiology, 519 Pt 3, 713-722 (1999-08-24)
1. To extend our knowledge of the site and mechanism of action of L-type Ca2+ channel antagonists on 5-HT3 receptors, whole-cell voltage clamp electrophysiology was used to investigate the action of one of these compounds, diltiazem, on the recombinant receptor
Determination of plasma protein binding of diltiazem in horses by ultrafiltration.
C C Schwarzwald et al.
Journal of veterinary pharmacology and therapeutics, 29(6), 579-580 (2006-11-07)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D2521-5G | 04061833562345 |
| D2521-1G | 04061835506217 |
| D2521-10G | 04061832961521 |