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D2141

6-重氮-5-氧代-L-正亮氨酸

Name: 6-重氮-5-氧代-<SC>L</SC>-正亮氨酸
Brand: SIGMA

≥95% (HPLC), suitable for ligand binding assays

别名:

DON, （S）-2-氨基-6-重氮-5-氧代己酸

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关于此项目

经验公式（希尔记法）:

C₆H₉N₃O₃

化学文摘社编号:

157-03-9

分子量:

171.15

NACRES:

NA.26

PubChem Substance ID:

24893639

UNSPSC Code:

12352209

MDL number:

MFCD00037218

Beilstein/REAXYS Number:

1725815

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属性

产品名称

6-重氮-5-氧代-L-正亮氨酸, powder

assay

≥95% (HPLC)

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

faint yellow, to yellow or tan

antibiotic activity spectrum

neoplastics

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O

InChI

1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1

InChI key

YCWQAMGASJSUIP-YFKPBYRVSA-N

说明

General description

化学结构：氨基酸衍生物

Application

6-重氮-5-氧代-L-正亮氨酸（DON）已用作谷氨酰胺合成酶 - 谷氨酰胺（酰胺）-2-氧代戊二酸氨基转移酶的抑制剂。

Biochem/physiol Actions

DON 与许多需要 L-谷氨酰胺作为氮源的反应有关，例如核酸和蛋白质合成。它已知具有抗绒毛膜癌的抗癌活性。

6-重氮-5-氧代-L-正亮氨酸（DON），谷氨酰胺类似物，用作抑制剂，研究胞苷三磷酸合成酶1（s）（CTPS1）和各种谷氨酰胺酶的功能、特异性和特征。DON 用于抑制细胞之间的谷氨酰胺（GLN）通量。

DON 用于研究谷氨酰胺利用酶的机制，例如氨基甲酰磷酸合成酶和胞苷三磷酸合成酶。

pictograms

GHS06

signalword

Danger

hcodes

H301 + H311 + H331

pcodes

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000530573

0000474367

0000474368

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