所有图片(1)
别名:
DON, （S）-2-氨基-6-重氮-5-氧代己酸
经验公式（希尔记法）:
C6H9N3O3
CAS号:
分子量:
171.15
Beilstein:
1725815
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
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检测方案
>95% (TLC)
质量水平
形式
crystalline
技术
ligand binding assay: suitable
颜色
light yellow
mp
145 °C
抗生素抗菌谱
neoplastics
作用机制
enzyme | inhibits
储存温度
−20°C
SMILES字符串
N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
InChI
1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
InChI key
YCWQAMGASJSUIP-YFKPBYRVSA-N
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相关类别
一般描述
化学结构：氨基酸衍生物
应用
6-重氮-5-氧代-L-正亮氨酸（DON）已用作谷氨酰胺合成酶 - 谷氨酰胺（酰胺）-2-氧代戊二酸氨基转移酶的抑制剂。
生化/生理作用
6-重氮-5-氧代-L-正亮氨酸（DON），谷氨酰胺类似物，用作抑制剂，研究胞苷三磷酸合成酶1（s）（CTPS1）和各种谷氨酰胺酶的功能、特异性和特征。DON 用于抑制细胞之间的谷氨酰胺（GLN）通量。
DON 与许多需要 L-谷氨酰胺作为氮源的反应有关，例如核酸和蛋白质合成。它已知具有抗绒毛膜癌的抗癌活性。
DON 用于研究谷氨酰胺利用酶的机制，例如氨基甲酰磷酸合成酶和胞苷三磷酸合成酶。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
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