D1159
地塞米松-21-磷酸二钠盐 二钠盐
≥98%, Glucocorticoid , powder
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关于此项目
经验公式（希尔记法）:
C22H28FNa2O8P
化学文摘社编号:
分子量:
516.40
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
51422340
EC Number:
219-243-0
MDL number:
Beilstein/REAXYS Number:
6473066
产品名称
地塞米松-21-磷酸二钠盐 二钠盐, ≥98%
InChI key
PLCQGRYPOISRTQ-FCJDYXGNSA-L
InChI
1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
SMILES string
[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O
assay
≥98%
form
powder
impurities
≤1% ethanol
color
white to off-white
storage temp.
2-8°C
Quality Level
Gene Information
human ... NR3C1(2908)
Application
Dexamethasone 21-phosphate disodium salt has been used:
- as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 (HSV-1) in the induced reactivation (IR) and spontaneous shedding (SS) rabbit models
- as a receptor analog to study its effects on glucocorticoid receptor activation in suprachiasmatic nuclei (SCN)-lesioned mice
- to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs
Biochem/physiol Actions
Dexamethasone 21-phosphate (Dex 21-P) is a pro-drug that can undergo dephosphorylation to form dexamethasone with the help of intra-erythrocyte enzymes. It exhibits therapeutic effects against cystic fibrosis and postoperative cataract. Dex 21-P disodium salt is a synthetic adrenal corticosteroid and possesses anti-inflammatory activity.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
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