生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
AS32, monoclonal
形式
buffered aqueous solution
种属反应性
human
浓度
~1 mg/mL
技术
neutralization: suitable
western blot: suitable
同位素/亚型
IgG1
UniProt登记号
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... CTLA4(1493)
一般描述
CD152 is structurally similar to CD28 and is a member of the immunoglobin (Ig) gene superfamily. The gene encoding human CD152 is present on chromosone 2. It is composed of a single Ig V-like extracellular domain, a transmembrnne domain, and an intracellular domain. It is mainly expressed by cytotoxic T lymphocytes and the level of expression is activation-dependent.
免疫原
recombinant extracellular domain of human CD152.
应用
Monoclonal Anti-CD152 antibody produced in mouse is suitable for western blotting and for neutralization studies, where this antibody has been shown to block the interaction of soluble human CD152 with human CD80.
生化/生理作用
CD152 and CD28 together with their ligands constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. CD152 acts as a co-stimulatory molecule in eliciting T cell help during antigen presentation and functions as a negative regulator of T cell activation.
目标描述
CD152, a cell surface glycoprotein, is one of two ligands (the other is CD28) for CD80 (B7-1) and CD86 (B7-2). This interaction appears to function as a negative regulator to T cell activation. CD152 is transiently expressed on activated T cells.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.
制备说明
Prepared from tissue culture supernatant, purified using protein G.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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