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Merck
CN

C9630

胞苷 2′:3′-环一磷酸 单钠盐

≥95% (HPLC), synthetic, powder

别名:

2′,3′-cCMP, 2′,3′-环 CMP 单钠盐, 环胞苷酸, 胞苷 2′,3′-环磷酸酯 钠盐

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关于此项目

经验公式(希尔记法):
C9H11N3NaO7P
化学文摘社编号:
分子量:
327.16
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
239-813-2
MDL number:
Beilstein/REAXYS Number:
4086446
Assay:
≥95% (HPLC)
Biological source:
synthetic
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
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产品名称

胞苷 2′:3′-环一磷酸 单钠盐, ≥95% (HPLC)

InChI

1S/C9H12N3O7P.Na/c10-5-1-2-12(9(14)11-5)8-7-6(4(3-13)17-8)18-20(15,16)19-7;/h1-2,4,6-8,13H,3H2,(H,15,16)(H2,10,11,14);/q;+1/p-1/t4-,6-,7-,8-;/m1./s1

InChI key

SQOIXCJUYWSZDW-IAIGYFSYSA-M

SMILES string

[Na+].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@H]3OP([O-])(=O)O[C@@H]23

biological source

synthetic

assay

≥95% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

Application

胞苷 2′,3′-环一磷酸(2′,3′-环胞苷一磷酸)(2′,3′-cCMP)被用作一种模型底物,用于各种核糖核酸酶(尤其是核糖核酸酶 A)动力学分析。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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M Ribó et al.
Protein expression and purification, 7(3), 253-261 (1996-05-01)
Human pancreatic ribonuclease (HP-RNase) has considerable promise as a therapeutic agent. Structure-function analyses of HP-RNase have been impeded by the difficulty of obtaining the enzyme from its host. Here, a gene encoding HP-RNase was designed, synthesized, and inserted into two
Pritam Roy et al.
Chemistry, an Asian journal, 14(24), 4780-4792 (2019-10-09)
Protein nitration can occur as a result of peroxynitrite-mediated oxidative stress. Excess production of peroxynitrite (PN) within the cellular medium can cause oxidative damage to biomolecules. The in vitro nitration of Ribonuclease A (RNase A) results in nitrotyrosine (NT) formation
J A Biosca et al.
European journal of biochemistry, 124(1), 151-156 (1982-05-01)
The study of the temperature dependence of the hydrolysis of cytidine 2',3'-phosphate by bovine pancreatic ribonuclease A (EC 3.1.27.5) at pH 7.0 by using the pH-stat method showed a transition at 4 degrees C [J. A. Biosca and C. M.
Isothermal titration calorimetric study of RNase-A kinetics (cCMP→ 3′-CMP) involving end-product inhibition.
Spencer SD, Raffa RB.
Pharmaceut. Res., 21, 1642-1647 (2004)
Mojca Bencina et al.
Journal of chromatography. A, 1144(1), 135-142 (2007-01-20)
In gene therapy and DNA vaccination, RNA removal from DNA preparations is vital and is typically achieved by the addition of ribonuclease into the sample. Removal of ribonuclease from DNA samples requires an additional purification step. An alternative is the

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