C9500
(±)-肉碱 盐酸盐
≥98% (TLC)
别名:
β-Hydroxy-γ-(trimethylammonio)butyrate 盐酸盐, (±)-Carnitine chloride, 盐酸盐
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关于此项目
线性分子式:
(CH3)3N(Cl)CH2CH(OH)CH2COOH
化学文摘社编号:
分子量:
197.66
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352107
EC Number:
207-309-1
MDL number:
Beilstein/REAXYS Number:
4163212
产品名称
(±)-肉碱 盐酸盐, ≥98% (TLC)
InChI key
JXXCENBLGFBQJM-UHFFFAOYSA-N
InChI
1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H
SMILES string
[Cl-].C[N+](C)(C)CC(O)CC(O)=O
assay
≥98% (TLC)
form
powder
color
white
Quality Level
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Application
DL-肉毒碱是具有活性的季铵盐立体异构体、 L-肉毒碱和无生物活性的 D-肉毒碱的外消旋混合物。DL-肉毒碱用于与纯异构体的比较研究。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
A A Spasov et al.
Vestnik Rossiiskoi akademii meditsinskikh nauk, 7(7), 20-27 (2006-08-24)
L-carnitine (L-beta-hydroxy-gamma-N,N,N-trimethylaminobutyric acid) is conditionally necessary for mitochondrial transport and metabolism of long-chain fatty acids, and thus for myocardial energetic metabolism. D-carnitine is not biologically active and might interfere with proper utilization of the L isomer, and so there are
A A Spasov et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 91(12), 1469-1480 (2006-02-24)
L-Carnitine (L-beta-hydroxy-gamma-N,N,N-trimethylaminobutyric acid) plays an essential role in fatty acid transport in the mitochondrion. Conditions that appear to benefit from exogenous supplementation of L-carnitine include anorexia, chronic fatigue, cardiovascular disease, hypoglycemia, male infertility, muscular myopathies, renal failure and dialysis. D-Carnitine
A A Spasov et al.
Bulletin of experimental biology and medicine, 142(4), 458-460 (2007-04-07)
Serum concentration of L-carnitine, the mean thickness of the skeletal muscle fiber, and exercise performance in the forced swimming test decreased in rats receiving a carnitine-deficient diet. Treatment with L-carnitine compensated for carnitine deficiency, while racemate and D-stereoisomer did not
Sophie Schobesberger et al.
eLife, 9 (2020-04-02)
Cardiomyocyte β3-adrenoceptors (β3-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messenger 3',5'-cyclic guanosine monophosphate (cGMP) have been shown to protect from heart failure. However, the exact localization of these receptors to fine membrane structures and subcellular compartmentation
Yan Wu et al.
Apoptosis : an international journal on programmed cell death, 20(8), 1099-1108 (2015-05-23)
AML (acute myeloid leukemia) cells have a unique reliance on mitochondrial metabolism and fatty acid oxidation (FAO). Thus, blocking FAO is a potential therapeutic strategy to target these malignant cells. In the current study, we assessed plasma membrane carnitine transporters
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