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C9377

鹅去氧胆酸

Name: 鹅去氧胆酸
Brand: SIGMA

别名:

3α，7α-二羟基-5β-胆汁酸, 5β-胆酸-3α，7α-二醇, 鹅去氧胆酸

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About This Item

经验公式（希尔记法）:

C₂₄H₄₀O₄

CAS号:

474-25-9

分子量:

392.57

Beilstein:

3219887

EC 号:

207-481-8

MDL编号:

MFCD00064142

UNSPSC代码:

12352106

PubChem化学物质编号:

24893153

NACRES:

NA.25

描述

anionic

质量水平

200

形式

powder

分子量

392.57 g/mol

技术

protein quantification: suitable

CMC

(3)
3

mp

165-167 °C (lit.)

官能团

carboxylic acid

运输

ambient

储存温度

room temp

SMILES字符串

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1

InChI key

RUDATBOHQWOJDD-BSWAIDMHSA-N

基因信息

human ... CYP1A2(1544) , NR1H4(9971)

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一般描述

鹅去氧胆酸是胆固醇在肝脏中合成的胆汁酸。

应用

鹅去氧胆酸已被用于一项评估其作为脑腱黄色瘤病（CTX）的长期替代疗法的效果的研究中。它也被用于一项研究其对回肠造口患者小肠吸收胆汁酸的影响的研究中。

生化/生理作用

胆汁酸

象形图

GHS07

警示用语：

Warning

危险声明

H315,H319

预防措施声明

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

危险分类

Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits.

M O Osman et al.

Gut, 43(2), 232-239 (1999-04-06)

Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis. To define the role of IL-8 in acute pancreatitis by neutralising its effects with a

Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids.

A Stiehl et al.

Gastroenterology, 98(2), 424-428 (1990-02-01)

The effects of ursodeoxycholic acid and chenodeoxycholic acid on the small-intestinal absorption of endogenous bile acids were studied in patients with ileostomies who served as a model to investigate small-intestinal absorption in humans. In the control period, the eight patients

Gallstone dissolution in man using chenodeoxycholic acid

Bell, G., et al.

Lancet, 300, 1213-1213 null

Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5.

Wei Zhou et al.

Journal of biomolecular screening, 15(5), 488-497 (2010-05-08)

Dietary long-chain fatty acid (LCFA) uptake across cell membranes is mediated principally by fatty acid transport proteins (FATPs). Six subtypes of this transporter are differentially expressed throughout the human and rodent body. To facilitate drugs discovery against FATP subtypes, the

Isolation and characterization of hydrophobic polypeptides in human bile.

M Stark et al.

European journal of biochemistry, 266(1), 209-214 (1999-10-29)

Polypeptides were isolated from human bile by extraction with chloroform/methanol, followed by reversed-phase chromatography in methanol/ethylene chloride and gel filtration in chloroform/methanol. Peptides were characterized by SDS/PAGE, sequence analysis and matrix-assisted laser desorption ionization/time-of-flight mass spectrometry. This identified haemoglobin alpha

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HPLC Separation of Bile Acids with Ascentis Express C18

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