C9282
胆酸钠 水合物
BioReagent, suitable for cell culture
别名:
3α,7α,12α-三羟基-5β-胆甾烷-24-羧酸 钠盐, 胆酸 钠盐
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选择尺寸
100 MG
¥436.96
500 MG
¥806.88
1 G
¥1,414.93
5 G
¥3,556.40
10 G
¥7,385.62
25 G
¥15,356.17
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变更视图
100 MG
¥436.96
500 MG
¥806.88
1 G
¥1,414.93
5 G
¥3,556.40
10 G
¥7,385.62
25 G
¥15,356.17
About This Item
经验公式（希尔记法）:
C24H39NaO5 · xH2O
CAS号:
分子量:
430.55 (anhydrous basis)
Beilstein:
3582354
EC 号:
MDL编号:
UNSPSC代码:
12161902
PubChem化学物质编号:
NACRES:
NA.75
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生物来源
bovine bile
ovine bile
质量水平
描述
anionic
产品线
BioReagent
方案
≥99.0% (HPLC)
表单
powder
分子量
micellar avg mol wt 900-1300
聚集数
2-3
技术
cell culture | mammalian: suitable
CMC
9-15 mM (20-25°C)
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此商品 | P3125 | P5306 | P3375 |
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable, single cell analysis: suitable | technique(s) - | technique(s) - | technique(s) - |
| specific activity ≥10 units/mg protein | specific activity ≥16 units/mg protein | specific activity ≥8.0 units/mg protein | specific activity 1.5-10 units/mg solid |
| form lyophilized powder | form buffered aqueous suspension | form lyophilized powder | form crude powder |
| application(s) diagnostic assay manufacturing | application(s) - | application(s) - | application(s) - |
| mol wt 23.4 kDa | mol wt 23.4 kDa | mol wt 23.4 kDa | mol wt 23.4 kDa |
应用
胆酸盐是肝脏在胆固醇分解过程中产生的一种胆酸。胆酸盐向下调节胆固醇-7α-羟化酶（胆汁酸合成中的限速步骤）。 胆酸盐是一种阴离子洗涤剂，可单独使用或与尿素一起使用，用于提取和重建膜蛋白和蛋白复合物。
生化/生理作用
12-α羟化酶活性的下降会导致肝脏疾病患者中胆酸水平降低。[2]
危险声明
预防措施声明
危险分类
Aquatic Chronic 3
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Proteome Profiling by Label-Free Mass Spectrometry Reveals Differentiated Response of Campylobacter jejuni 81-176 to Sublethal Concentrations of Bile Acids
Masanta WO, et al.
Proteomics. Clinical Applications, 13(3), 1800083-1800083 (2019)
John Y L Chiang
Journal of lipid research, 50(10), 1955-1966 (2009-04-07)
Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and cell signaling pathways that regulate
Solubilization and reconstitution characteristics of hepatic system A-mediated amino acid transport.
P Fafournoux et al.
The Journal of biological chemistry, 264(9), 4805-4811 (1989-03-25)
In the liver, System A-mediated uptake of neutral amino acids may play a key role in metabolic control. Knowing the properties of the solubilized and reconstituted System A activity is important for future studies on the purification of the carrier
Mahendra Singh et al.
Cell biochemistry and biophysics, 48(1), 54-72 (2007-08-19)
Upregulation of the scaffolding protein HEF1, also known as NEDD9 and Cas-L, has recently been identified as a pro-metastatic stimulus in a number of different solid tumors, and has also been strongly associated with pathogenesis of BCR-Abl-dependent tumors. As the
A Ambesi et al.
Analytical biochemistry, 198(2), 312-317 (1991-11-01)
Solubilization and reconstitution of the cardiac sarcolemmal Na+/Ca2+ exchanger by use of the anionic detergent cholate and its application for reconstitution of the exchanger following solubilization with zwitterionic or nonionic detergents is described. Solubilization and reconstitution with cholate provided a
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