C9137
5′-三磷酸虫草素 钠盐
≥95%
别名:
3′-dATP, 3′-脱氧-ATP, 3′-脱氧腺苷-5′-三磷酸
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关于此项目
经验公式（希尔记法）:
C10H16N5O12P3
化学文摘社编号:
分子量:
491.18
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
产品名称
5′-三磷酸虫草素 钠盐, ≥95%
InChI
1S/C10H16N5O12P3.Na.H/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-6,10,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;
SMILES string
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)CC3O
InChI key
FRGBONDYLMUOMH-UHFFFAOYSA-N
assay
≥95%
form
powder
mol wt
491.18 g/mol
storage temp.
−20°C
Quality Level
Application
5′-三磷酸虫草素钠盐已用于：
- 作为RNA降解检测的转录抑制剂
- 在收获前抑制HEK293T细胞的多腺苷化，通过免疫共沉淀(co-Ips)法进行体外相互作用研究
- 作为聚合酶抑制的体外检测实验中的阳性对照
- 作为生产虫草素单磷酸的前体
Biochem/physiol Actions
虫草素 5′-三磷酸盐通过 poly (A) 聚合酶掺入核酸中。因为它缺少一个 3′-羟基链的产生，它可用于 3′-RNA 的末端标记。
虫草素可激活人类AMP活化蛋白激酶(AMPK)，发挥多种代谢功能。三磷酸虫草素通过体外阻断[3H]GMP掺入来抑制微小核糖核酸病毒(picornavirus)聚合酶特异性RNA合成。它也可抑制RNA合成而延缓细胞生长。
General description
虫草素（Cordycepin，3′-脱氧腺苷）是从蛹虫草Cordyceps militaris中提取的细胞毒性腺苷类似物和生物活性试剂。5′-三磷酸虫草素是虫草素的毒性衍生物。
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Martin M Gossner et al.
Nature, 540(7632), 266-269 (2016-12-06)
Land-use intensification is a major driver of biodiversity loss. Alongside reductions in local species diversity, biotic homogenization at larger spatial scales is of great concern for conservation. Biotic homogenization means a decrease in β-diversity (the compositional dissimilarity between sites). Most
Ming Wei Chen et al.
Antiviral research, 143, 38-47 (2017-04-10)
Chikungunya virus (CHIKV) is an important arboviral infectious agent in tropical and subtropical regions, often causing persistent and debilitating disease. The viral enzyme non-structural protein 4 (nsP4), as RNA-dependent RNA polymerase (RdRP), catalyzes the formation of negative-sense, genomic and subgenomic
D L Panicali et al.
Journal of virology, 25(1), 124-128 (1978-01-01)
Cordycepin triphosphate inhibited in vitro [3H]GMP incorporation by pricornavirus-specific polymerase complexes isolated from infected HeLa cells. The inhibition of [3H]GMP incorporation could be reversed with ATP added to the reaction mixture along with the inhibitor, but not with GTP so
3′-end labeling of RNA with recombinant yeast poly(A) polymerase.
Lingner J, Keller W.
Nucleic Acids Research, 25, 2917-2920 (1993)
Nicole Montreau et al.
Comptes rendus biologies, 326(12), 1135-1147 (2004-01-30)
Using an in vivo heterologous system to study the stability of Xenopus laevis RNA injected into axolotl (Ambystoma mexicanum) fertilized eggs, we have previously observed unexpected fluctuations in RNA level during early development [Andéol et al., Differentiation 63 (1998) 69-79].
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