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质量水平
检测方案
≥95%
形式
powder
分子量
491.18 g/mol
储存温度
−20°C
SMILES字符串
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)CC3O
InChI
1S/C10H16N5O12P3.Na.H/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-6,10,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;
InChI key
FRGBONDYLMUOMH-UHFFFAOYSA-N
相关类别
一般描述
虫草素（Cordycepin，3′-脱氧腺苷）是从蛹虫草Cordyceps militaris中提取的细胞毒性腺苷类似物和生物活性试剂。5′-三磷酸虫草素是虫草素的毒性衍生物。
应用
5′-三磷酸虫草素钠盐已用于：
- 作为RNA降解检测的转录抑制剂
- 在收获前抑制HEK293T细胞的多腺苷化，通过免疫共沉淀(co-Ips)法进行体外相互作用研究
- 作为聚合酶抑制的体外检测实验中的阳性对照
- 作为生产虫草素单磷酸的前体
生化/生理作用
虫草素可激活人类AMP活化蛋白激酶(AMPK)，发挥多种代谢功能。三磷酸虫草素通过体外阻断[3H]GMP掺入来抑制微小核糖核酸病毒(picornavirus)聚合酶特异性RNA合成。它也可抑制RNA合成而延缓细胞生长。
虫草素 5′-三磷酸盐通过 poly (A) 聚合酶掺入核酸中。因为它缺少一个 3′-羟基链的产生，它可用于 3′-RNA 的末端标记。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Junhua Pan et al.
Nature, 577(7789), 275-279 (2019-11-08)
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) cause severe respiratory diseases in infants and elderly adults1. No vaccine or effective antiviral therapy currently exists to control RSV or HMPV infections. During viral genome replication and transcription, the tetrameric phosphoprotein
G Costanzo et al.
Molecular and cellular biology, 21(9), 3166-3178 (2001-04-05)
Quantitative analysis of multiple-hit potassium permanganate (KMnO(4)) footprinting has been carried out in vivo on Saccharomyces cerevisiae 5S rRNA genes. The results fix the number of open complexes at steady state in exponentially growing cells at between 8 and 17%
Lisa S Chen et al.
British journal of haematology, 140(6), 682-391 (2008-01-22)
Multiple myeloma (MM) is an incurable plasma cell malignancy that is slow-growing, and thus traditional DNA-replication directed chemotherapeutics are ineffective. We hypothesized that those agents that target RNA-directed processes would be successful in MM. To test this postulate, cordycepin, a
Martin M Gossner et al.
Nature, 540(7632), 266-269 (2016-12-06)
Land-use intensification is a major driver of biodiversity loss. Alongside reductions in local species diversity, biotic homogenization at larger spatial scales is of great concern for conservation. Biotic homogenization means a decrease in β-diversity (the compositional dissimilarity between sites). Most
D L Panicali et al.
Journal of virology, 25(1), 124-128 (1978-01-01)
Cordycepin triphosphate inhibited in vitro [3H]GMP incorporation by pricornavirus-specific polymerase complexes isolated from infected HeLa cells. The inhibition of [3H]GMP incorporation could be reversed with ATP added to the reaction mixture along with the inhibitor, but not with GTP so
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