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产品名称
硫胺素焦磷酸, ≥95%
质量水平
方案
≥95%
表单
powder
溶解性
H2O: soluble 50 mg/mL, clear to very slightly hazy, colorless
储存温度
−20°C
SMILES字符串
CC1=C(CCOP(OP(O)(O)=O)(O)=O)SC=[N+]1CC2=C(N)N=C(C)N=C2.[Cl-]
InChI
1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H
InChI key
YXVCLPJQTZXJLH-UHFFFAOYSA-N
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应用
Sigma的硫胺素焦磷酸用作底物,以检测从大鼠组织分离的高尔基体片层中的酶。
硫胺焦磷酸盐已被用于:
- 制备壳聚糖纳米粒子
- 在高性能
- 液相色谱(HPLC)分析中,作为维生素B1及其衍生物的标准品
- 免疫荧光
生化/生理作用
硫胺焦磷酸盐(TPP)是一种转酮醇酶的辅酶,可催化5-磷酸核糖的裂解。该反应可生成D-甘油醛-3-磷酸。该反应需要加入受体醛,例如核糖-5-磷酸、甘油醛或乙醇醛。TPP能够在′受体醛′存在下使羟基丙酮酸脱羧。
警示用语:
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种:
分析证书(COA)
Immunofluorescence Analysis of Human Endocervical Tissue Explants Infected with Neisseria gonorrhoeae
Bio-protocol, 8(3) (2018)
Nucleosidediphosphatase activity in the Golgi apparatus and its usefulness for cytological studies.
Proceedings of the National Academy of Sciences of the United States of America, 47, 802-810 (1961-06-15)
Thiamine pyrophosphate, a coenzyme of transketolase
Journal of the American Chemical Society, 75(4), 1010-1011 (1953)
Effects of anti-CD44 monoclonal antibody IM7 carried with chitosan polylactic acid-coated nano-particles on the treatment of ovarian cancer
Oncology Letters, 13(1), 99-104 (2017)
Nucleic acids research, 41(5), 3022-3031 (2013-02-05)
Thiamin pyrophosphate (TPP) riboswitches are found in organisms from all three domains of life. Examples in bacteria commonly repress gene expression by terminating transcription or by blocking ribosome binding, whereas most eukaryotic TPP riboswitches are predicted to regulate gene expression
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