推荐产品
产品名称
L -胱硫醚, ≥98% (TLC)
质量水平
方案
≥98% (TLC)
表单
powder
技术
UHPLC: suitable
颜色
white
mp
>300 °C
储存温度
−20°C
SMILES字符串
N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
InChI
1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1
InChI key
ILRYLPWNYFXEMH-WHFBIAKZSA-N
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相关类别
应用
L-胱硫醚已被用于超高效液相色谱中,用于验证胱硫醚及其丰度与脊椎动物变态的相关性。 它还被用作窦状GSH(谷胱甘肽)载体的抑制剂,以表明巯基氧化还原状态失衡与癌细胞中自噬的调节有关。
生化/生理作用
L-胱硫醚是 L-半胱氨酸和蛋氨酸生物合成的中间体。 作为底物用于分化分析胱硫醚 γ-裂解酶。L-胱硫醚是一种重要的非蛋白氨基酸,与代谢紊乱有关。在最近的研究中,L-胱硫醚被认为是环亚氨基环硫氨酸的前体。胱硫醚尿症的特征是尿中排出亚氨基酸环硫氨酸。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Cystathionine gamma-lyase of Streptomyces phaeochromogenes. The occurrence of cystathionine gamma-lyase in filamentous bacteria and its purification and characterization.
The Journal of Biological Chemistry, 259(16), 10393-10403 (1984)
The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase.
European Journal of Biochemistry, 157(1), 57-63 (1986)
Nutrition (Burbank, Los Angeles County, Calif.), 26(11-12), 1201-1204 (2010-01-19)
Dietary methionine restriction in Fischer-344 rats favorably influences visceral fat mass, insulin sensitivity, metabolic parameters, and longevity. However, little is known about the effects of methionine restriction on serum methionine and its downstream sulfur amino acids. We investigated the serum
Journal of the American Chemical Society, 133(40), 15866-15869 (2011-09-09)
The two disulfide bonds of α-conotoxin ImI, a peptide antagonist of the α7 nicotinic acetylcholine receptor (nAChR), were systematically replaced with isosteric redox-stable cystathionine thioethers. Regioselective thioether formation was accomplished on solid support through substitution of a γ-chlorohomoalanine by an
Synthesis and evaluation of L-cystathionine as a standard for amino acid analysis.
Bioscience, Biotechnology, and Biochemistry, 81(1), 95-101 (2017)
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