重组
expressed in E. coli
质量水平
检测方案
>90% (SDS-PAGE)
形式
lyophilized powder
比活
8,000 units/mg protein (Bradford)
分子量
~30 kDa
溶解性
PBS: soluble
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CASP10(843)
生化/生理作用
Caspase 10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase 10 cleaves and activates caspases 3, 4, 6, 7, 8 and 9 which causes the proteolytic cleavage of many key proteins such as PARP. Based on gene expression studies, caspase 10 may be crucial in embryonic development. In view of its structural homology to caspase 8, the initiator caspase in death receptor-mediated apoptosis, caspase 10 may function in a similar and redundant manner.
单位定义
One unit will hydrolyze 1 nmol of the caspase substrate IETD-pNA to IETD and p-nitroaniline per hour at pH 7.2 at 37 °C.
外形
Lyophilized powder containing 0.052% ammonium sulfate, 0.158% Tris−HCl, and 0.76% sodium chloride.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Caspases: the executioners of apoptosis.
Cohen, G.M.
Biochemistry, 326 (part 1), 1-1 (1997)
Marcin Poreba et al.
Nature protocols, 12(10), 2189-2214 (2017-09-22)
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates and probes. It is, however, difficult to find substrate sequences that are truly selective for any given protease, as different proteases can demonstrate
Marcin Poreba et al.
Nature protocols, 12(10), 2189-2214 (2017-09-22)
Many biologically and chemically based approaches have been developed to design highly active and selective protease substrates and probes. It is, however, difficult to find substrate sequences that are truly selective for any given protease, as different proteases can demonstrate
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