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安全信息

C5913

Sigma-Aldrich

4-氯汞苯甲酸

cysteine active site modifier

别名:

4-氯苯甲酸汞, 对氯汞苯甲酸

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About This Item

线性分子式:
ClHgC6H4CO2H
CAS号:
59-85-8
分子量:
357.16
Beilstein:
3662892
EC 号:
200-442-6
MDL编号:
MFCD00002526
UNSPSC代码:
12352202
PubChem化学物质编号:
24278323
NACRES:
NA.77

描述

cysteine active site modifier

方案

≥98.5% (HPLC)

表单

powder

mp

287 °C (dec.) (lit.)

溶解性

1 M NaOH: 20 mg/mL, clear, colorless

SMILES字符串

OC(=O)c1ccc([Hg]Cl)cc1

InChI

1S/C7H5O2.ClH.Hg/c8-7(9)6-4-2-1-3-5-6;;/h2-5H,(H,8,9);1H;/q;;+1/p-1

InChI key

YFZOUMNUDGGHIW-UHFFFAOYSA-M

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应用

Can be used to inhibit some enzymes that require unmodified cysteine residues (e.g., adenylyl cyclase).

免责声明

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

警示用语：

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
STBJ8646
STBJ7475
076K1087
125K1080
102H3641

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Gabriela Galicia-Vázquez et al.
Analytical biochemistry, 384(1), 180-188 (2008-10-18)
Protein-RNA interactions are involved in all facets of RNA biology. The identification of small molecules that selectively block such bimolecular interactions could provide insight into previously unexplored steps of gene regulation. Such is the case for regulation of eukaryotic protein
Vardan T Karamyan et al.
European journal of pharmacology, 590(1-3), 87-92 (2008-06-24)
In the present study the existence of a non-AT(1), non-AT(2) angiotensin (Ang) binding site unmasked by the organomercurial protease inhibitor p-chloromercuribenzoate (PCMB) was demonstrated in mouse brain membranes, consistent with observations previously reported in the rat (Karamyan and Speth, 2007b).
Suresh Katragadda et al.
International journal of pharmaceutics, 320(1-2), 104-113 (2006-05-25)
The aim of this study is to identify the class of enzymes responsible for the hydrolysis of amino acid and dipeptide prodrugs of acyclovir (ACV) and to modulate transport and metabolism of amino acid and dipeptide prodrugs of acyclovir by
Mamoon Rashid et al.
The Journal of pharmacology and experimental therapeutics, 335(3), 754-761 (2010-09-24)
We have discovered a non-AT(1), non-AT(2) angiotensin binding site in rodent and human brain membranes, which, based on its pharmacological/biochemical properties and tissue distribution, is different from angiotensin receptors and key proteases processing angiotensins. In this study, the novel angiotensin
Margaret Yole et al.
Toxicology, 231(1), 40-57 (2007-01-11)
The effects of 1 min-4 h exposures to four Hg compounds (mercuric chloride [HgCl2], methyl mercuric chloride [CH3HgCl], p-chloromercuribenzoate [p-CMB] and thimerosal [TMS; ethylmercurithiosalicylate]) on cell death, microtubules, actin, CD3 receptor expression, protein tyrosine phosphorylation (PTyr-P) and intracellular calcium ([Ca2+]i)
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