C5438
8-（4-氯苯硫基）-鸟苷 3′,5′-环单磷酸 钠盐
≥95% (HPLC), cGMP dependent protein kinase (PKG) activator, powder
别名:
8-pCPT-cGMP, pCPT-cGMP
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关于此项目
经验公式（希尔记法）:
C16H14ClN5NaO7PS
化学文摘社编号:
分子量:
509.79
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
8-（4-氯苯硫基）-鸟苷 3′,5′-环单磷酸 钠盐, ≥95% (HPLC), powder
color
white
SMILES string
[Na+].NC1=Nc2c(nc(Sc3ccc(Cl)cc3)n2[C@@H]4O[C@@H]5COP([O-])(=O)O[C@H]5[C@H]4O)C(=O)N1
InChI
1S/C16H15ClN5O7PS.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11;/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-;/m1./s1
InChI key
REEQGIQRCDWDRA-ZBMQJGODSA-M
assay
≥95% (HPLC)
form
powder
solubility
H2O: 25 mg/mL
storage temp.
−20°C
Quality Level
Application
8-（4-氯苯硫基）-鸟苷 3′,5‘-环状单磷酸钠盐已被用于激活血管平滑肌细胞（VSMC）中的GMP依赖性蛋白激酶（PKG）。
Biochem/physiol Actions
cGMP的膜渗透性类似物，不影响cGMP调节的磷酸二酯酶。 比8-Br-cGMP更有效的cGMP类似物，因为它具有更高的膜渗透性和更高的抗磷酸二酯酶水解能力。用作cGMP依赖性蛋白激酶（PKG）的选择性激活剂。被发现是一种非常有效的环状核苷酸门控通道激动剂。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
J Y Wei et al.
Journal of molecular neuroscience : MN, 10(1), 53-64 (1998-05-20)
Cyclic nucleotide-gated (CNG) channels are expressed in many cell types in both the nervous system and nonexcitable tissues. In order to understand the roles of cGMP-gated channels, and to distinguish actions of cGMP mediated through CNG channels from those through
Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis
Pallero MA, et al.
Journal of Vascular Research, 47(4), 309-322 (2010)
Hypoxic depression of PKG-mediated inhibition of serotonergic contraction in ovine carotid arteries.
Richard B Thorpe et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R734-R743 (2013-03-01)
Chronic hypoxia attenuates soluble guanylate cyclase-induced vasorelaxation in serotonin (5-HT)-contracted ovine carotid arteries. Because protein kinase G (PKG) mediates many effects of soluble guanylate cyclase activation through phosphorylation of multiple kinase targets in vascular smooth muscle, we tested the hypothesis
Yang Chen et al.
Circulation research, 124(10), 1462-1472 (2019-04-02)
Acute kidney injury (AKI) has a high prevalence and mortality in critically ill patients. It is also a powerful risk factor for heart failure incidence driven by hemodynamic changes and neurohormonal activation. However, no drugs have been approved by the
P He et al.
The American journal of physiology, 274(6 Pt 2), H1865-H1874 (1998-06-25)
To investigate the mechanisms whereby guanosine 3',5'-cyclic monophosphate (cGMP) modulates microvessel permeability in vivo, we measured changes in microvessel hydraulic conductivity (Lp) and endothelial cytoplasmic Ca2+ concentration ([Ca2+]i) in response to the cGMP analogs 8-bromo-cGMP (8-BrcGMP) and 8-(p-chlorophenylthio)cGMP (8-pCPT-cGMP) in
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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