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安全信息

C3042

Sigma-Aldrich

Corticotropin Releasing Factor human, rat

≥95% (HPLC), powder

别名:

CRF, CRH

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About This Item

经验公式（希尔记法）:
C208H344N60O63S2
CAS号:
86784-80-7
分子量:
4757.45
MDL编号:
MFCD00213806
UNSPSC代码:
12352200
NACRES:
NA.32

生物来源

human
rat

质量水平

200

检测方案

≥95% (HPLC)

形式

powder

分子量

4757.45

储存条件

(Keep container tightly closed in a dry and well-ventilated place)

技术

activity assay: suitable

溶解性

water: 1.00-1.04 mg/mL, colorless

UniProt登记号

P06850

储存温度

−20°C

InChI key

VXFVFWFSJFSXHN-FAUHKOHMSA-N

基因信息

human ... CRH(1392)

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Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

一般描述

The corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, the hypothalamus, and the amygdala.

Research area: Neuroscience

应用

Corticotropin Releasing Factor human, rat has been used:
  • as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants
  • as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells
  • in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture
  • in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

生化/生理作用

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Corticotropin-releasing factor modulates stress responses. It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders. Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.

其他说明

Lyophilized from 0.1% TFA in H2O

抗体

产品编号
说明
价格

C5348

抗-促肾上腺皮质激素释放因子 兔抗, IgG fraction of antiserum, buffered aqueous solution

C0961

Corticotropin Releasing Factor Fragment 6-33 human, rat, ≥97% (HPLC)

C3042

Corticotropin Releasing Factor human, rat, ≥95% (HPLC), powder

A4933

Astressin, ≥90% (HPLC)

C2917

Corticotropin Releasing Factor Antagonist, ≥97% (HPLC)

C2671

Corticotropin Releasing Factor bovine, ≥90% (HPLC), Synthetic

WH0001392M2

Monoclonal Anti-CRH antibody produced in mouse, clone 2B11, purified immunoglobulin, buffered aqueous solution

GW22056

Anti-CRH antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

SAB1405656

Anti-CRH antibody produced in mouse, purified immunoglobulin, buffered aqueous solution

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solubility of Corticotropin Releasing Factor human, rat (C3042)?

    Based on our quality control testing, Corticotropin Releasing Factor human, rat (C3042) is soluble in water at a concentration of 1 mg/ml.

  6. What is the solution stability of Corticotropin Releasing Factor human, rat (C3042)?

    Sigma has not tested Corticotropin Releasing Factor human, rat (C3042) for solution stability or for stability in culture.  The following article looks at the stability of corticotropin releasing factor: Acta Med Okayama. 1985 Jun;39(3):199-206.   

  7. What is the difference between the peptide content and the purity of Corticotropin Releasing Factor human, rat (C3042)?

    The peptide content of Corticotropin Releasing Factor human, rat (C3042) is determined by amino acid analysis (AAA) and distinguishes how much of the product is actually peptide.  The purity of Corticotropin Releasing Factor human, rat (C3042) is determined by HPLC and distinguishes how much of the peptide found is Corticotropin Releasing Factor human, rat (C3042).

  8. What is the counter ion in Corticotropin Releasing Factor human, rat (C3042)?

    Corticotropin Releasing Factor human, rat (C3042) is lyophilized from 0.1% TFA in water.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation
Simard M, et al.
Reproductive Biology and Endocrinology, 8(1), 134-134 (2010)
A Slominski
The British journal of dermatology, 160(2), 229-232 (2009-02-04)
Corticotropin-releasing hormone (CRH; previously known as corticotropin-releasing factor) is the central regulator of the hypothalamic-pituitary-adrenal (HPA) axis, which is the main organizer of the body’s response to stress.– Stress induces the hypothalamic production and release of CRH, which then causes
Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and corticosterone
Thome UH, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 284(2), L376-L385 (2003)
Salt appetite
Vitamins & Hormones (2017)
Transcriptional regulation of hypothalamic corticotropin-releasing factor gene
Vitamins & Hormones, 82, 301-317 (2010)
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