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质量水平
检测方案
≥98% (HPLC)
形式
solid
储存条件
desiccated
颜色
off-white
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
InChI
1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
InChI key
CGDGXEDXEXACKQ-UHFFFAOYSA-N
应用
Antalarmin 盐酸盐是一种非肽 CRF1 促肾上腺皮质激素释放因子受体拮抗剂。
Antalarmin盐酸盐的应用示例：
- 研究其对压力诱导的色氨酸羟化酶2活性的影响
- 研究促肾上腺皮质激素释放因子(CRF1)活化介导的焦虑作用
- 分析其阻断促肾上腺皮质激素(CRH)信号传导对社会压力诱导的抑郁的治疗作用
生化/生理作用
Antalarmin是非类固醇的怀孕抑制剂，即使在妊娠早期也能起到抑制效用。目前已确定它可延迟分娩。它还可抑制压力诱导的胃溃疡发展。
Antalarmin 盐酸盐是一种非肽 CRF1 促肾上腺皮质激素释放因子受体拮抗剂。
特点和优势
在《受体分类和信号转导》手册的 促肾上腺皮质激素释放因子受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
CRF type 1 receptors of the medial amygdala modulate inhibitory avoidance responses in the elevated T-maze
Vicentini JE, et al.
Hormones and Behavior, 65(3), 195-202 (2014)
Pediatric Neuroendocrinology, 41-41 (2010)
Cecile Ducottet et al.
Progress in neuro-psychopharmacology & biological psychiatry, 27(4), 625-631 (2003-06-06)
Several recent studies on corticotropin-releasing factor (CRF) have suggested that this neuropeptide may play a role in depression. Consequently, CRF receptor antagonists have been proposed as potential new agents for the treatment of this condition. This study investigated the effects
Rapid stress-induced transcriptomic changes in the brain depend on beta-adrenergic signaling
Roszkowski M, et al.
Neuropharmacology, 107, 329-338 (2016)
Anna Skórzewska et al.
Stress (Amsterdam, Netherlands), 22(1), 113-122 (2018-10-23)
This study aimed to test the hypothesis that high-anxiety (HR) rats are more sensitive to the effects of chronic corticosterone administration and antalarmin (corticotropin-releasing factor (CRF) receptor 1, CRF1 antagonist) injections than low-anxiety (LR) rats, and this effect is accompanied
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