生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
human, mouse, rat
技术
immunocytochemistry: suitable
western blot: 1:200 using rat heart membranes
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CACNA1C(775)
mouse ... Cacna1c(12288)
rat ... Cacna1c(24239)
特异性
可识别小鼠Cav1.2，大鼠Cav1.2的剪接变体P22002-4和P22002-5，以及兔Cav1.2的剪接变体P15381-4。
免疫原
对应于人Cav1.2残基2-15的多肽（外显子1B）。该序列的14/15个残基与小鼠和大鼠体内的相同。
生化/生理作用
L型电压依赖性钙通道α1C亚基（Cav1.2）是人类CACNA1C基因编码的蛋白质，属于电压门控钙通道家族。它是细胞表面膜电位变化到可引发不同生理事件的局部细胞内钙瞬变的关键转导蛋白。CACNA1C是L型电压依赖性钙通道的亚基。它定位于染色体12p13.3，并被认为是精神分裂症的易感基因。CACNA1C在人TH2细胞中选择性表达，阻断TH2细胞Cav1.2通道激活可能是治疗人类受试者过敏性疾病的新策略。其活性增加与痴呆和阿尔茨海默病（AD）的发病机制有关。′
目标描述
钙通道CaV1.2（CACNA1C）编码电压依赖性钙通道的α-1亚基。钙离子通道在膜极化时介导钙离子流入细胞。
外形
由含有1% BSA和0.05% 叠氮化钠的pH 7.4的磷酸盐缓冲液冻干。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Fanfan Zheng et al.
Schizophrenia research, 152(1), 105-110 (2013-12-21)
CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether
William A Catterall et al.
Pharmacological reviews, 57(4), 411-425 (2005-12-31)
The family of voltage-gated calcium channels serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events. There are 10 members of the voltage-gated calcium channel family that have
Virginie Robert et al.
The Journal of allergy and clinical immunology, 133(4), 1175-1183 (2013-12-25)
In addition to calcium release-activated calcium channel/ORAI calcium channels, the role of voltage-gated calcium (Cav1) channels in T-cell calcium signaling is emerging. Cav1 channels are formed by α1 (CaV1.1 to CaV1.4) and auxiliary subunits. We previously demonstrated that mouse TH2
Nina Daschil et al.
Journal of Alzheimer's disease : JAD, 37(2), 439-451 (2013-08-21)
Increased activity of L-type Ca2+ channels has been implicated in the pathogenesis of dementia and Alzheimer's disease (AD). Previously we detected CaV1.2 α1-subunit-positive expression in reactive astrocytes surrounding the plaques of 12 month-old transgenic mice overexpressing hAβPP751 with the London
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