跳转至内容
Merck
CN

C101

Sigma-Aldrich

8-环戊基-1,3-二丙基黄嘌呤

solid

别名:

1,3-二丙基-8-环戊基黄嘌呤, DPCPX, PD 116948

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C16H24N4O2
分子量:
304.39
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77

表单

solid

质量水平

颜色

white

溶解性

DMSO: >10 mg/mL
0.1 M NaOH: 2 mg/mL
ethanol: 4 mg/mL
H2O: insoluble

εmax

14,800 at 276 nm in ethanol

SMILES字符串

CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)C3CCCC3

InChI

1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)

InChI key

FFBDFADSZUINTG-UHFFFAOYSA-N

正在寻找类似产品? 访问 产品对比指南

应用

8-环戊基-1,3-二丙基黄嘌呤作为腺苷受体(A1AR)拮抗剂,用于巨噬细胞 和人脐静脉内皮细胞(HUVEC)。 它也作为A1AR拮抗剂,用于MCF-7乳腺癌细胞系,试验其抗癌作用。

生化/生理作用

8-环戊基-1,3-二丙基黄嘌呤(DPCPX)是选择性的A1腺苷受体拮抗剂。DPCPX具有抗癌功能。诱导乳腺癌细胞凋亡,有利于胱天蛋白酶mRNA表达。

特点和优势

《受体分类和信号转导》手册的 腺苷受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Lindsay Silva et al.
Neurotoxicology and teratology, 58, 88-100 (2016-02-24)
Adolescents who use marijuana are more likely to exhibit anxiety, depression, and other mood disorders, including psychotic-like symptoms. Additionally, the age at onset of use and the stress history of the individual can affect responses to cannabis. To examine the
Vanessa R Haynes et al.
Molecular metabolism, 34, 54-71 (2020-03-18)
Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and the mechanisms by which
Mehdi Nikbakht Dastjerdi et al.
Research in pharmaceutical sciences, 11(4), 303-310 (2016-09-22)
Adenosine receptor family especially A1 type is expressed in breast cancer cells in which P53 and caspase genes are wild-type. The aim of this study was to investigate the correlation between A1 receptor and either cell apoptosis or proliferation and
João M N Duarte et al.
Frontiers in neuroscience, 12, 1015-1015 (2019-01-29)
Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term caffeine consumption prevents type 2
Carola Ledderose et al.
Purinergic signalling, 12(4), 673-685 (2016-09-01)
In neutrophils, adenosine triphosphate (ATP) release and autocrine purinergic signaling regulate coordinated cell motility during chemotaxis. Here, we studied whether similar mechanisms regulate the motility of breast cancer cells. While neutrophils and benign human mammary epithelial cells (HMEC) form a

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门